The use of antisense oligonucleotides in skin lightening products Journal Article

  


Authors: Bautista, M.; Lockett, F.; Mecca, J.; Sawatdeekhachornphat, W.; Castro, A.; Yarlagadda, S.; Gonzalez, S.; Philips, N.
Article Title: The use of antisense oligonucleotides in skin lightening products
Abstract: Developments in gene sequencing, safety, specificity and simplicity of the concept have resulted in the investigation and development of antisense oligonucleotides as therapeutic agents. Most current skin lighteners work to inhibit tyrosinase to deactivate melanin synthesis, leading to lighter and brighter skin. Antisense oligonucleotides work by interfering with the gene expression of tyrosinase, and the production of melanin ceases as a result. Topical application of antisense oligonucleotides is effective on pigmented spots and non-pigmented skin. Antisense technology is in its early stages and additional trials with proper controls should be conducted to ensure efficacy, proper specificity, and safety.
Keywords: gene sequence; ultraviolet radiation; gene expression; melanin; skin pigmentation; melanocyte; pruritus; drug mechanism; messenger rna; carcinogenicity; acne; hyperpigmentation; monophenol monooxygenase; dry skin; tyrosinase related protein 1; absence of side effects; melanogenesis; skin redness; hydroquinone; chloasma; tyrosinase related protein 2; skin burning sensation; ferulic acid; skin color; retinitis; 2 hydroxyacid; cosmetics; anti-sense oligonucleotides; brightening; antisense oligonucleotide; arbutin; cosmetic; fomivirsen; guaiacol; kojic acid; resorcinol; antisense therapy; melanosome
Journal Title: Journal of Plastic Dermatology
Volume: 4
Issue: 1
ISSN: 1473-2130
Publisher: International-Italian Society of Plastic and Oncologic Dermatology  
Date Published: 2008-01-01
Start Page: 17
End Page: 19
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-43349083363&partnerID=40&md5=052f86039d352cbf335c691c1acda257
Notes: --- - "Export Date: 17 November 2011" - "Source: Scopus"