Assignment of the human TYRP (brown) locus to chromosome region 9p23 by nonradioactive in situ hybridization Journal Article
| Authors: | Murty, V. V. V. S.; Bouchard, B.; Mathew, S.; Vijayasaradhi, S.; Houghton, A. N. |
| Article Title: | Assignment of the human TYRP (brown) locus to chromosome region 9p23 by nonradioactive in situ hybridization |
| Abstract: | The TYRP (brown) locus determines pigmentation and coat color in the mouse. The human homolog of the TYRP locus has been recently identified and shown to encode a 75-kDa transmembrane melanosomal glycoprotein called gp75. The gp75 glycoprotein is homologous to tyrosinase, an enzyme involved in the synthesis of melanin, forming a family of tyrosinase-related proteins. A genomic clone of human gp75 was used to map the human TYRP locus to chromosome 9, region 9p23, by nonradioactive fluorescent in situ hybridization. Specificity of hybridization was tested with a genomic fragment of human tyrosinase that mapped to a distinct site on 11q21. The 9p region has been reported to be nonrandomly altered in human melanoma, suggesting a role for the region near the TYRP locus in melanocyte transformation. © 1992. |
| Keywords: | sensitivity and specificity; melanoma; fluorescence; chromosome 9p; gene locus; chromosomes, human, pair 9; pigmentation; in situ hybridization; membrane glycoproteins; monophenol monooxygenase; nucleic acid hybridization; sequence homology, nucleic acid; gene location; human; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; gene assignment |
| Journal Title: | Genomics |
| Volume: | 13 |
| Issue: | 1 |
| ISSN: | 0888-7543 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1992-05-01 |
| Start Page: | 227 |
| End Page: | 229 |
| Language: | English |
| DOI: | 10.1016/0888-7543(92)90228-k |
| PUBMED: | 1577487 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
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