Effect of calcium citrate supplementation on urinary calcium oxalate saturation in female stone formers: Implications for prevention of osteoporosis Journal Article

  

Authors:	Levine, B. S.; Rodman, J. S.; Wienerman, S.; Bockman, R. S.; Lane, J. M.; Chapman, D. S.
Article Title:	Effect of calcium citrate supplementation on urinary calcium oxalate saturation in female stone formers: Implications for prevention of osteoporosis
Abstract:	In 14 women aged 37-68 y with a history of renal calcium calculi, bone densities were 12.0% below those of age-matched control subjects at the L2-4 lumbar spine (P = 0.007) and 6.4% less at the femoral neck (P = 0.095). A low-oxalate diet was supplemented with 1 g Ca/d as citrate. In 6 mo, plasma 1,25(OH)(2)D concentrations fell from 53.2 +/- 18.8 to 41.9 +/- 15.2 ng/L (P = 0.02) and parathyroid hormone from 39.1 +/- 17.0 to 30.8 +/- 12.5 ng/L (P = 0.02). Calcium oxalate saturation was 2.15 +/- 1.38 at baseline, 2.27 +/- 1.00 at 1 mo, and 2.06 +/- 1.57 at 6 mo. The increase in urinary calcium at 1 mo from 4.411 +/- 1.87 to 6.514 +/- 2.82 mmol/24 h (P = 0.01) was offset by a parallel increase in citrate excretion from 2.909 +/- 1.45 to 3.455 +/- 1.34 mmol/24 h (P = 0.03). Calcium citrate supplementation did not increase the lithogenicity of the women in this protocol.
Keywords:	risk; osteoporosis; hormone; parathyroid hormone; bone-mineral density; excretion; vitamin-d; kidney stones; calcium citrate; calcium absorption; 1,25(oh)(2)d
Journal Title:	American Journal of Clinical Nutrition
Volume:	60
Issue:	4
ISSN:	0002-9165
Publisher:	American Society for Nutrition
Date Published:	1994-10-01
Start Page:	592
End Page:	596
Language:	English
ACCESSION:	WOS:A1994PJ93000018
PROVIDER:	wos
PUBMED:	8092096
DOI:	10.1093/ajcn/60.4.592
Notes:	Article -- Source: Wos

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