Finding and Drugging the Vulnerabilities of RAS-Dependent Cancers Journal Article
| Author: | Sawyers, C. L. |
| Article Title: | Finding and Drugging the Vulnerabilities of RAS-Dependent Cancers |
| Abstract: | Kinase inhibitors have ushered in the era of targeted therapy, but their utility to date is primarily limited to cancers bearing oncogenic kinase mutations. Two papers in this issue (Luo et al., 2009; Scholl et al., 2009) could change this landscape by uncovering kinase-specific vulnerabilities in tumors with RAS mutations. © 2009 Elsevier Inc. All rights reserved. |
| Keywords: | cancer survival; gene mutation; mutation; cancer growth; nonhuman; drug targeting; paclitaxel; neoplasms; bortezomib; gene amplification; rna interference; cancer cell culture; cytotoxicity; cell line, tumor; protein serine threonine kinase; wild type; protein kinase inhibitors; cancer genetics; polo like kinase 1; malignant neoplastic disease; short survey; genome; ras protein; ras proteins; k ras protein; tumor gene; phosphotransferase; short hairpin rna; phosphotransferase inhibitor; mutant; 4 [4 (4' chloro 2 biphenylylmethyl) 1 piperazinyl] n [4 [3 dimethylamino 1 (phenylthiomethyl)propylamino] 3 nitrobenzenesulfonyl]benzamide; isocitrate dehydrogenase |
| Journal Title: | Cell |
| Volume: | 137 |
| Issue: | 5 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2009-05-29 |
| Start Page: | 796 |
| End Page: | 798 |
| Language: | English |
| DOI: | 10.1016/j.cell.2009.05.011 |
| PUBMED: | 19490885 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "CODEN: CELLB" - "Source: Scopus" |
