KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib Journal Article
| Authors: | Pao, W.; Wang, T. Y.; Riely, G. J.; Miller, V. A.; Pan, Q.; Ladanyi, M.; Zakowski, M. F.; Heelan, R. T.; Kris, M. G.; Varmus, H. E. |
| Article Title: | KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib |
| Abstract: | Background: Somatic mutations in the gene for the epidermal growth factor receptor (EGFR) are found in adenocarcinomas of the lung and are associated with sensitivity to the kinase inhibitors gefitinib (Iressa) and erlotinib (Tarceva). Lung adenocarcinomas also harbor activating mutations in the downstream GTPase, KRAS, and mutations in EGFR and KRAS appear to be mutually exclusive. Methods and Findings: We sought to determine whether mutations in KRAS could be used to further enhance prediction of response to gefitinib or erlotinib. We screened 60 lung adenocarcinomas defined as sensitive or refractory to gefitinib or erlotinib for mutations in EGFR and KRAS. We show that mutations in KRAS are associated with a lack of sensitivity to either drug. Conclusion: Our results suggest that treatment decisions regarding use of these kinase inhibitors might be improved by determining the mutational status of both EGFR and KRAS. © 2005 Pao et al. |
| Keywords: | cancer chemotherapy; clinical article; controlled study; human tissue; unclassified drug; gene mutation; erlotinib; epidermal growth factor receptor; protein; prediction; lung adenocarcinoma; gefitinib; phosphotransferase inhibitor; protein kras |
| Journal Title: | PLos Medicine |
| Volume: | 2 |
| Issue: | 1 |
| ISSN: | 1549-1277 |
| Publisher: | Public Library of Science |
| Date Published: | 2005-01-01 |
| Start Page: | 0057 |
| End Page: | 0061 |
| Language: | English |
| DOI: | 10.1371/journal.pmed.0020017 |
| PROVIDER: | scopus |
| PMCID: | PMC545207 |
| PUBMED: | 15696205 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 704" - "Export Date: 24 October 2012" - "Source: Scopus" |
