Novel tracers and their development for the imaging of metastatic prostate cancer Journal Article

   


Authors: Apolo, A. B.; Pandit-Taskar, N.; Morris, M. J.
Article Title: Novel tracers and their development for the imaging of metastatic prostate cancer
Abstract: There are presently no accurate methods of imaging prostate cancer metastases to bone. An unprecedented number of novel imaging agents, based on the biology of the disease, are now available for testing. We reviewed contemporary molecular imaging modalities that have been tested in humans with metastatic prostate cancer, with consideration of the studies' adherence to current prostate cancer clinical trial designs. Articles from the years 2002 to 2008 on PET using 18F-FDG, 11C-choline, 18F-choline, 18F-flouride, 11C-acetate, 11C-methionine, and 18F-fluoro-5α- dihydrotestosterone in patients with metastatic prostate cancer were reviewed. Although these studies are encouraging, most focus on the rising population with prostate-specific antigen, and many involve small numbers of patients and do not adhere to consensus criteria for clinical trial designs in prostate cancer. Hence, although many promising agents are available for testing, such studies would benefit from closer collaboration between those in the fields of medical oncology and nuclear medicine. Copyright © 2008 by the Society of Nuclear Medicine, Inc.
Keywords: unclassified drug; nonhuman; clinical trials as topic; positron emission tomography; radiopharmaceuticals; prostate specific antigen; consensus; metastasis; molecular imaging; diagnostic imaging; oncology; prostate cancer; prostatic neoplasms; capromab pendetide in 111; prostate specific membrane antigen; isotope labeling; image enhancement; fluorodeoxyglucose f 18; medronate technetium tc 99m; computer assisted emission tomography; positron-emission tomography; radiopharmaceutical agent; patient compliance; amino acid; nuclear medicine; tracer; fluorine 18; acetic acid c 11; choline c 11; fatty acid; bone scintiscanning; osteoblast; fluoro 5alpha dihydrotestosterone f 18; fatty acid synthesis; methionine c 11; phospholipid; 18f- fluorodeoxyglucose; 11c-acetate; 11c-choline; 11c-methionine; 18f-fluoro-5α- dihydrotestosterone; 18f-fluorocholine; positronemission tomography; choline f 18
Journal Title: Journal of Nuclear Medicine
Volume: 49
Issue: 12
ISSN: 0161-5505
Publisher: Society of Nuclear Medicine  
Date Published: 2008-12-01
Start Page: 2031
End Page: 2041
Language: English
DOI: 10.2967/jnumed.108.050658
PUBMED: 18997047
PROVIDER: scopus
PMCID: PMC3310891
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-57149084500&partnerID=40&md5=d4996f7654c36d6ef90bd01d84cb16cf
Notes: --- - "Cited By (since 1996): 28" - "Export Date: 17 November 2011" - "CODEN: JNMEA" - "Source: Scopus"
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Michael Morris
    566 Morris
  2. Andrea Borghese Apolo
    7 Apolo
  3. Neeta Pandit-Taskar
    340 Pandit-Taskar
Related MSK Work