The role of imaging in the detection of prostate cancer local recurrence after radiation therapy and surgery Journal Article
| Authors: | Pucar, D.; Sella, T.; Schoder, H. |
| Article Title: | The role of imaging in the detection of prostate cancer local recurrence after radiation therapy and surgery |
| Abstract: | PURPOSE OF REVIEW: The aim of this article is to review novel MRI and nuclear medicine methods for detecting and planning salvage treatment for prostate cancer local recurrence after radical prostatectomy or radiation therapy. RECENT FINDINGS: Traditional methods for detecting local recurrence (i.e., digital rectal exam or transrectal ultrasound and digital rectal exam or transrectal ultrasound-guided biopsy) have limited accuracy in determining the presence and extent of local recurrence and therefore have limited ability to guide salvage therapy. Recent studies indicate that conventional T1 and T2-weighted prostate MRI could improve the detection of recurrent prostate cancer after radical prostatectomy or radiation therapy and salvage treatment planning. Promising new sequences could further increase the accuracy of MRI. In addition, the use of technically improved PET/computed tomography scanners with new tracers like C and F choline and acetate might offer better assessment of recurrent prostate cancer than F-2-fluoro-D-deoxyglucose-PET and monoclonal antibody imaging with the prostate specific membrane antigen antibody In-capromab pendetide (ProstaScint). SUMMARY: With systemic therapies for recurrent prostate cancer after radical prostatectomy or radiation therapy being noncurative, the application of MRI and nuclear medicine modalities can help to identify patients who have isolated local recurrence amenable to salvage treatment. © 2008 Lippincott Williams & Wilkins, Inc. |
| Keywords: | cancer surgery; treatment failure; unclassified drug; review; cancer localization; cancer recurrence; salvage therapy; cancer radiotherapy; nuclear magnetic resonance imaging; magnetic resonance imaging; prostate specific antigen; neoplasm recurrence, local; diagnostic imaging; prostate cancer; prostatic neoplasms; capromab pendetide in 111; monoclonal antibody j591; prostatectomy; fluorodeoxyglucose f 18; computer assisted emission tomography; radiopharmaceutical agent; nuclear medicine; acetic acid c 11; choline c 11; local recurrence; choline f 18 |
| Journal Title: | Current Opinion in Urology |
| Volume: | 18 |
| Issue: | 1 |
| ISSN: | 0963-0643 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2008-01-01 |
| Start Page: | 87 |
| End Page: | 97 |
| Language: | English |
| DOI: | 10.1097/MOU.0b013e3282f13ac3 |
| PUBMED: | 18090496 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 29" - "Export Date: 17 November 2011" - "CODEN: CUOUE" - "Source: Scopus" |
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