Epidemiology of renal cell carcinoma Journal Article


Authors: Capitanio, U.; Bensalah, K.; Bex, A.; Boorjian, S. A.; Bray, F.; Coleman, J.; Gore, J. L.; Sun, M.; Wood, C.; Russo, P.
Article Title: Epidemiology of renal cell carcinoma
Abstract: Context: Despite the improvement in renal cell carcinoma (RCC) diagnosis and management observed during the last 2 decades, RCC remains one of the most lethal urological malignancies. With the expansion of routine imaging for many disorders, an increasing number of patients who harbour RCC are identified incidentally. Objective: To summarise and compare RCC incidence and mortality rates, analyse the magnitude of risk factors, and interpret these epidemiological observations in the context of screening and disease management. Evidence acquisition: The primary objective of the current review was to retrieve and describe worldwide RCC incidence/mortality rates. Secondly, a narrative literature review about the magnitude of the known risk factors was performed. Finally, data retrieved from the first two steps were elaborated to define the clinical implications for RCC screening. Evidence synthesis: RCC incidence and mortality significantly differ among individual countries and world regions. Potential RCC risk factors include behavioural and environmental factors, comorbidities, and analgesics. Smoking, obesity, hypertension, and chronic kidney disease represent established risk factors. Other factors have been associated with an increased RCC risk, although selection biases may be present and controversial results have been reported. Conclusions: Incidence of RCC varies worldwide. Within the several RCC risk factors identified, smoking, obesity, and hypertension are most strongly associated with RCC. In individuals at a higher risk of RCC, the cost effectiveness of a screening programme needs to be assessed on a country-specific level due to geographic heterogeneity in incidence and mortality rates, costs, and management implications. Owing to the low rates of RCC, implementation of accurate biomarkers appears to be mandatory. Patient summary: The probability of harbouring kidney cancer is higher in developed countries and among smokers, obese individuals, and individuals with hypertension. Renal cell carcinoma (RCC) incidence and mortality rates vary significantly around the globe. Risk factors for RCC are smoking, obesity, hypertension, and chronic kidney disease. In individuals at a higher risk of RCC, the cost effectiveness of a screening programme needs to be assessed on a country specific level. Owing to the low incidence of RCC, there is an unmet need for accurate biomarkers. © 2018 European Association of Urology
Keywords: mortality; review; hypertension; cancer incidence; incidence; prevalence; obesity; cancer screening; smoking; risk factor; renal cell carcinoma; cancer mortality; europe; body mass; diabetes mellitus; comorbidity; liver disease; asia; physical activity; kidney cancer; epidemiology; alcohol consumption; environmental factor; chronic kidney failure; analgesic agent; lifestyle; africa; renal cancer; urolithiasis; pacific islands; human; priority journal
Journal Title: European Urology
Volume: 75
Issue: 1
ISSN: 0302-2838
Publisher: Elsevier Science, Inc.  
Date Published: 2019-01-01
Start Page: 74
End Page: 84
Language: English
DOI: 10.1016/j.eururo.2018.08.036
PUBMED: 30243799
PROVIDER: scopus
DOI/URL:
Notes: Review -- Export Date: 1 February 2019 -- Source: Scopus
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MSK Authors
  1. Jonathan Coleman
    181 Coleman
  2. Paul Russo
    443 Russo