Kidney cancer Journal Article
| Authors: | Motzer, R. J.; Agarwal, N.; Beard, C.; Bolger, G. B.; Boston, B.; Carducci, M. A.; Choueiri, T. K.; Figlin, R. A.; Fishman, M.; Hancock, S. L.; Hudes, G. R.; Jonasch, E.; Kessinger, A.; Kuzel, T. M.; Lange, P. H.; Levine, E. G.; Margolin, K. A.; Michaelson, M. D.; Olencki, T.; Pili, R.; Redman, B. G.; Robertson, C. N.; Schwartz, L. H.; Sheinfeld, J.; Wang, J. |
| Article Title: | Kidney cancer |
| Abstract: | In 2008, an estimated 54,390 Americans were diagnosed with and 13,010 died of kidney cancer in the United States. The rate of renal cell carcinoma (RCC) has increased 2% per year for the past 65 years. Smoking and obesity are among the risk factors for RCC development, with tumor grade, local extent of the tumor, presence of regional nodal metastases, and evidence of metastatic disease at presentation the most important prognostic determinants of 5-year survival. These guidelines discuss evaluation, staging, treatment, and management after treatment. Important updates for 2009 include the addition of everolimus as second-line therapy after a tyrosine kinase inhibitor and the change to a category 1 recommendation for bevaciumab and interferon for first-line therapy for clear cell histologies. © Journal of the National Comprehensive Cancer Network 2009. |
| Keywords: | cancer survival; cancer surgery; gene mutation; clinical trial; disease course; fatigue; neutropenia; review; sorafenib; bevacizumab; doxorubicin; fluorouracil; interferon; placebo; sunitinib; cancer risk; diarrhea; dose response; drug efficacy; drug potentiation; drug safety; hypertension; multimodality cancer therapy; side effect; clinical trials as topic; alpha interferon; capecitabine; gemcitabine; adjuvant therapy; chemotherapy, adjuvant; combined modality therapy; cancer staging; drug megadose; cancer diagnosis; neoplasm staging; cancer palliative therapy; interleukin 2; low drug dose; metastasis; drug eruption; infection; pain; kidney disease; stomatitis; thrombocytopenia; nccn clinical practice guidelines; practice guideline; tumor biopsy; pathology; renal cell carcinoma; hematuria; kidney carcinoma; kidney neoplasms; nephrectomy; protein tyrosine kinase inhibitor; temsirolimus; drug dose escalation; hyperglycemia; lung metastasis; cytokine; drug mechanism; kidney tumor; carcinoma, renal cell; adjuvant chemotherapy; scoring system; neoplasm metastasis; peripheral edema; cancer relapse; lactate dehydrogenase; flu like syndrome; clear cell carcinoma; hypercholesterolemia; von hippel lindau disease; amylase blood level; hand foot syndrome; floxuridine; epistaxis; everolimus; proteinuria; hyperlipidemia; clear cell tumors; non clear cell carcinoma |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 7 |
| Issue: | 6 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2009-06-01 |
| Start Page: | 618 |
| End Page: | 630 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 19555584 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 30 November 2010" - "Source: Scopus" |
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