Breast implant-associated anaplastic large cell lymphoma: Clinical and imaging findings at a large US cancer center Journal Article


Authors: Dashevsky, B. Z.; Gallagher, K. M.; Grabenstetter, A.; Cordeiro, P. G.; Dogan, A.; Morris, E. A.; Horwitz, S. M.; Sutton, E. J.
Article Title: Breast implant-associated anaplastic large cell lymphoma: Clinical and imaging findings at a large US cancer center
Abstract: Purpose: Evaluate the clinical presentation and imaging findings of breast implant-associated anaplastic large cell lymphoma (BIA ALCL) at a large US cancer center. Materials and Methods: HIPAA-compliant IRB approved retrospective study, for which informed consent was waived. The Hospital Information System was screened for women who underwent implant reconstruction and were diagnosed with BIA ALCL between 2010 and 2016. Two radiologists reviewed images in consensus. Clinical and imaging characteristics were summarized using means and ranges for continuous variables and percentages for categorical variables. Results: Patient cohort included 11 women with BIA ALCL (mean age at diagnosis = 54 years, range: 35-77), including women with (9/11) and without (2/11) history of breast cancer. Mean time from breast implant placement to diagnosis was 10 years (range: 6-14). BIA ALCL was identified in patients with saline (4/11) and silicone (5/11) implants. Implants were textured in 7/11 (63%) and unknown in 4/11 (36%) cases. All patients presented with a peri-implant seroma, (9/11 documented on imaging). Two of 11 patients had a mass within this seroma. Ten of 11 patients (91%) presented with symptoms. Conclusions: Saline and silicone breast implants may predispose patients to a rare lymphoma subtype, BIA ALCL, which presents on imaging as a peri-implant fluid collection ± mass. © 2018 Wiley Periodicals, Inc.
Journal Title: Breast Journal
Volume: 25
Issue: 1
ISSN: 1075-122X
Publisher: Wiley Blackwell  
Date Published: 2019-01-01
Start Page: 69
End Page: 74
Language: English
DOI: 10.1111/tbj.13161
PUBMED: 30521149
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 1 February 2019 -- Source: Scopus
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MSK Authors
  1. Elizabeth A Morris
    239 Morris
  2. Steven M Horwitz
    343 Horwitz
  3. Peter G Cordeiro
    238 Cordeiro
  4. Elizabeth Jane Sutton
    26 Sutton
  5. Ahmet Dogan
    162 Dogan