Genetic predictors of response to acupuncture for aromatase inhibitor-associated arthralgia among breast cancer survivors Journal Article


Authors: Genovese, T. J.; Mao, J. J.
Article Title: Genetic predictors of response to acupuncture for aromatase inhibitor-associated arthralgia among breast cancer survivors
Abstract: Objective: To evaluate the associations between polymorphisms in two genes, catechol-O-methyltransferase and T-cell leukemia/lymphoma 1 A, and acupuncture-mediated pain reduction among breast cancer survivors with aromatase inhibitor-associated arthralgia. Design, Setting, and Subjects: Biospecimens were obtained from 38 patients enrolled in a clinical trial of acupuncture for aromatase inhibitor-associated arthralgia in postmenopausal hormone receptor-positive breast cancer survivors. Methods: We used polymerase chain reaction to genotype the rs4680 (Val158Met) and rs4633 (His62His) variants in the catechol-O-methyltransferase gene and rs2369049 (A > G) and rs7158782 (A > G) variants in the T-cell leukemia/lymphoma 1 A gene. Response to acupuncture was defined by 30% reduction in end-of-treatment average pain, measured by the Brief Pain Inventory. We used Fisher exact tests to evaluate associations between genotype and treatment response. Results: Among participants, all six (15.8%) subjects who expressed AA in locus rs4680 responded to acupuncture. In a combined analysis, the 18 (47.4%) subjects with the responder genotype at either rs4680 (AA) or rs2369049 (GG or AG) were significantly more likely to respond to acupuncture than those without (77.8% vs 45.0%, P = 0.039). Conclusions: Specific genetic variations at loci rs4680 and rs2369049 are associated with response to acupuncture-type intervention for management of arthralgia. These results serve as a proof of concept for applying a precision medicine framework to the study of cancer pain management.
Journal Title: Pain Medicine
Volume: 20
Issue: 1
ISSN: 1526-2375
Publisher: Oxford University Press  
Date Published: 2019-01-01
Start Page: 191
End Page: 194
Language: English
DOI: 10.1093/pm/pny067
PUBMED: 29912452
PROVIDER: scopus
PMCID: PMC6329437
DOI/URL:
Notes: Export Date: 1 February 2019 -- Source: Scopus
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  1. Jun J Mao
    60 Mao