Anti-opioid activity of sigma(1) systems Journal Article


Author: Pasternak, G.
Article Title: Anti-opioid activity of sigma(1) systems
Abstract: (+)Pentazocine is a potent sigma1 ligand which antagonizes mu, kappa1, kappa3 and delta analgesia. This antagonism is reversed by haloperidol, which blocks both D2 and sigma receptors, but not by sulpiride, a selective D2 drug without sigma activity. Haloperidol (< 1 mg/kg) shifts the dose-response curves for morphine in CD-1 mice approximately 2-fold and is more effective against kappa analgesics. These shifts argue for a tonic activity of this anti-opioid system. This anti-opioid system also contributes to the differences in opioid sensitivity among strains of mice. © 1994.
Keywords: controlled study; nonhuman; conference paper; mouse; haloperidol; animal experiment; animalia; morphine; analgesia; opiate receptor; enkephalin[2,5 dextro penicillamine]; pentazocine; 3,4 dichloro n methyl n [2 (1 pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate; naloxone benzoylhydrazone; priority journal
Journal Title: Regulatory Peptides
Volume: 54
Issue: 1
ISSN: 0167-0115
Publisher: Elsevier BV  
Date Published: 1994-11-10
Start Page: 219
End Page: 220
Language: English
DOI: 10.1016/0167-0115(94)90469-3
PROVIDER: scopus
DOI/URL:
Notes: CODEN: REPPD -- Source: Scopus
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  1. Gavril W Pasternak
    414 Pasternak
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