Anti-opioid activity of sigma(1) systems Journal Article
| Author: | Pasternak, G. |
| Article Title: | Anti-opioid activity of sigma(1) systems |
| Abstract: | (+)Pentazocine is a potent sigma1 ligand which antagonizes mu, kappa1, kappa3 and delta analgesia. This antagonism is reversed by haloperidol, which blocks both D2 and sigma receptors, but not by sulpiride, a selective D2 drug without sigma activity. Haloperidol (< 1 mg/kg) shifts the dose-response curves for morphine in CD-1 mice approximately 2-fold and is more effective against kappa analgesics. These shifts argue for a tonic activity of this anti-opioid system. This anti-opioid system also contributes to the differences in opioid sensitivity among strains of mice. © 1994. |
| Keywords: | controlled study; nonhuman; conference paper; mouse; haloperidol; animal experiment; animalia; morphine; analgesia; opiate receptor; enkephalin[2,5 dextro penicillamine]; pentazocine; 3,4 dichloro n methyl n [2 (1 pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate; naloxone benzoylhydrazone; priority journal |
| Journal Title: | Regulatory Peptides |
| Volume: | 54 |
| Issue: | 1 |
| ISSN: | 0167-0115 |
| Publisher: | Elsevier BV |
| Date Published: | 1994-11-10 |
| Start Page: | 219 |
| End Page: | 220 |
| Language: | English |
| DOI: | 10.1016/0167-0115(94)90469-3 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | CODEN: REPPD -- Source: Scopus |
