| Abstract: |
In mice, activation of sigma, receptors antagonizes opioid analgesia. Sigma antagonists potentiate opioid analgesia, implying that the anti-opioid sigma system is tonically active. Co-administration of haloperidol with the mu opioid morphine, the kappa1 analgesic U50,488H or the kappa3 agonist naloxone benzoylhydrazone enhances the analgesic activity of all agents. The effect results from sigma receptor blockade since (-)sulpiride, a selective D2 antagonist which does not block sigma receptors, is inactive. © 1995. |
| Keywords: |
controlled study; unclassified drug; nonhuman; animal; haloperidol; animal experiment; drug synergism; rat; rats; rats, sprague-dawley; morphine; pain measurement; analgesics; analgesia; mu opiate receptor; naloxone; pyrrolidines; opiate antagonist; receptors, sigma; 3,4 dichloro n methyl n [2 (1 pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate; kappa opiate receptor; opioid analgesia; subcutaneous drug administration; narcotics; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; 3,4-dichloro-n-methyl-n-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-isomer; sulpiride; sigma, receptors; naloxone derivative
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