Characterization of the promoter region of the gene for the rat neutral and basic amino acid transporter and chromosomal localization of the human gene Journal Article

   

Authors:	Yan, N.; Mosckovitz, R.; Gerber, L. D.; Mathew, S.; Murty, V. V. V. S.; Tate, S. S.; Udenfriend, S.
Article Title:	Characterization of the promoter region of the gene for the rat neutral and basic amino acid transporter and chromosomal localization of the human gene
Abstract:	The promoter region of the rat kidney neutral and basic amino acid transporter (NBAT) gene has been isolated and sequenced. The major transcription initiation site was mapped by primer extension. The entire promoter region and a set of 5' deletions within it were expressed at a high level in LLC-PK1 cells using the luciferase indicator gene. Positive and negative regulatory elements in the promoter region were observed. A human genomic clone of the transporter was also obtained and was used to localize the NBAT gene at the p21 region of chromosome 2.
Keywords:	gene sequence; promoter region; sequence analysis; nonhuman; comparative study; genetic analysis; animal cell; animal; transcription initiation; transcription, genetic; chromosomes, human, pair 2; animalia; cloning, molecular; gene mapping; amino acid sequence; molecular sequence data; nucleotide sequence; carrier proteins; rat; base sequence; rats; amino acids; chromosome 2; biological transport; amino acid transport; chromosomal localization; chromosome mapping; sequence analysis, dna; regulator gene; gene isolation; promoter regions (genetics); human; priority journal; article
Journal Title:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	91
Issue:	16
ISSN:	0027-8424
Publisher:	National Academy of Sciences
Date Published:	1994-08-02
Start Page:	7548
End Page:	7552
Language:	English
DOI:	10.1073/pnas.91.16.7548
PROVIDER:	scopus
PMCID:	PMC44439
PUBMED:	8052618
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028025452&doi=10.1073%2fpnas.91.16.7548&partnerID=40&md5=bc7fd7089fd8bf28f0dc462964b4352b
Notes:	Export Date: 14 January 2019 -- Article -- CODEN: PNASA C2 -- Source: Scopus

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