A family of cellular proteins related to snake venom disintegrins Journal Article
| Authors: | Weskamp, G.; Blobel, C. P. |
| Article Title: | A family of cellular proteins related to snake venom disintegrins |
| Abstract: | Disintegrins are short soluble integrin ligands that were initially identified in snake venom. A previously recognized cellular protein with a disintegrin domain was the guinea pig sperm protein PH-30, a protein implicated in sperm-egg membrane binding and fusion. Here we present peptide sequences that are characteristic for several cellular disintegrin-domain proteins. These peptide sequences were deduced from cDNA sequence tags that were generated by polymerase chain reaction from various mouse tissues and a mouse muscle cell line. Northern blot analysis with four sequence tags revealed distinct mRNA expression patterns. Evidently, cellular proteins containing a disintegrin domain define a superfamily of potential integrin ligands that are likely to function in important cell-cell and cell-matrix interactions. |
| Keywords: | nonhuman; polymerase chain reaction; protein domain; animal cell; mouse; animal tissue; cell protein; animalia; extracellular matrix; amino acid sequence; messenger rna; ligand; protein family; cell interaction; cell adhesion; integrin; complementary dna; metalloprotease; cell fusion; northern blotting; snake venom; priority journal; article; sus scrofa; cavia porcellus; serpentes; integrin ligand |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 91 |
| Issue: | 7 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 1994-03-29 |
| Start Page: | 2748 |
| End Page: | 2751 |
| Language: | English |
| DOI: | 10.1073/pnas.91.7.2748 |
| PROVIDER: | scopus |
| PMCID: | PMC43447 |
| PUBMED: | 8146185 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- CODEN: PNASA C2 -- Source: Scopus |
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