Clinical comparison of radiolocalization of two monoclonal antibodies (mAbs) against the TAG-72 antigen Journal Article
| Authors: | Divgi, C. R.; Scott, A. M.; McDermott, K.; Fallone, P. S.; Hilton, S.; Siler, K.; Carmichael, N.; Daghighian, F.; Finn, R. D.; Cohen, A. M.; Schlom, J.; Larson, S. M. |
| Article Title: | Clinical comparison of radiolocalization of two monoclonal antibodies (mAbs) against the TAG-72 antigen |
| Abstract: | Ten patients with colorectal cancer metastases received 125I-B72.3 and 131I-CC49 prior to laparotomy (five patients received 1 mg, and five 20 mg of each mAb). Tumor:serum ratios of 131I-CC49 were better than those of 125I-B72.3 (P < 0.01 at 1 mg; P = 0.05 at 20 mg; P < 0.01 at both doses). All known lesions ≥ 1 cm in diameter were visualized at the 20 mg dose. There was no difference in absolute tumor uptake of 125I-B72.3 or 131I-CC49. We conclude that mAb CC49 has better relative uptake in colorectal cancers than mAb B72.3. © 1994. |
| Keywords: | adult; clinical article; aged; unclassified drug; liver neoplasms; comparative study; colorectal cancer; recurrence; monoclonal antibody; colorectal neoplasms; liver metastasis; antibodies, monoclonal; antigens, neoplasm; iodine radioisotopes; pelvic neoplasms; radioimmunotherapy; glycoproteins; intravenous drug administration; adrenal gland neoplasms; tomography, emission-computed, single-photon; middle age; immunoconjugates; immunoscintigraphy; tag 72 antigen; human; male; female; article; monoclonal antibody cc49; monoclonal antibody i 125; monoclonal antibody b.72.3 i 125 |
| Journal Title: | Nuclear Medicine and Biology |
| Volume: | 21 |
| Issue: | 1 |
| ISSN: | 0969-8051 |
| Publisher: | Elsevier Science Inc. |
| Date Published: | 1994-01-01 |
| Start Page: | 9 |
| End Page: | 15 |
| Language: | English |
| DOI: | 10.1016/0969-8051(94)90124-4 |
| PROVIDER: | scopus |
| PUBMED: | 9234259 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- CODEN: NMBIE C2 -- Source: Scopus |
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