Preselection of patients with high TAG-72 antigen expression leads to targeting of 94% of known metastatic tumor sites with monoclonal antibody I-131-CC49 Journal Article

  

Authors:	Kostakoglu, L.; Divgi, C. R.; Hilton, S.; Cordon-Cardo, C.; Scott, A. M.; Kalaigian, H.; Finn, R. D.; Schlom, J.; Larson, S. M.
Article Title:	Preselection of patients with high TAG-72 antigen expression leads to targeting of 94% of known metastatic tumor sites with monoclonal antibody I-131-CC49
Abstract:	We studied 18 consecutive patients with advanced colorectal cancer where primary tumors were preselected for high expression of TAG-72 antigen and who underwent a phase I radioimmunotherapy trial with an intravenously administered monoclonal antibody CC49, 20 mg, labeled with 1-131 in amounts varying from 15 mCi/m2 to 75 mCi/m2. Whole-body images and SPECT of the abdomen obtained I week after infusion were compared with pretreatment CT scans. A total of 66 lesions were evaluated. SPECT revealed 2/66 lesions (3% that were not detected by CT; 4/66 were only detected by CT: lungs (1.8 cm and <1 cm), axilla (1.5 cm), adrenal (2.5 cm). Thus, based on immunohistopathological testing in paraffin-embedded tissue blocks of primary tumors stained for TAG-72 antigen, we have selected a subset of patients (about 70% of referrals) with colorectal cancer for whom I-131-CC49 was shown to target to 62/64 CT positive lesions (97% and 62/66 (94% of all known positive lesions. We conclude that in patients with significant TAG-72 tumor expression there is excellent targeting of 1-131-CC49 in therapeutic doses to colorectal cancer with respect to lesions detected with CT scanning. It should be noted that this study was not designed as a comparison of the sensitivity of CT versus 1-131-CC49 SPECT/planar imaging. Instead, the observed results are consistent with a biological hypothesis that in general, the primary tumor histology vis-a-vis TAG-72 expression reflects the TAG-72 expression of the metastatic sites. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Keywords:	adult; clinical article; aged; unclassified drug; clinical trial; patient selection; liver neoplasms; comparative study; colorectal cancer; metastasis; computer assisted tomography; tomography, x-ray computed; tumor antigen; colorectal neoplasms; antibodies, monoclonal; antigens, neoplasm; iodine 131; iodine radioisotopes; scintiscanning; phase 1 clinical trial; radioimmunotherapy; glycoproteins; intravenous drug administration; tomography, emission-computed, single-photon; middle age; immunotoxins; radioimmunodetection; tag 72 antigen; human; male; female; priority journal; article; monoclonal antibody cc49; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; monoclonal antibody i 131
Journal Title:	Cancer Investigation
Volume:	12
Issue:	6
ISSN:	0735-7907
Publisher:	Informa Healthcare
Date Published:	1994-01-01
Start Page:	551
End Page:	558
Language:	English
DOI:	10.3109/07357909409023039
PROVIDER:	scopus
PUBMED:	7994589
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028036787&doi=10.3109%2f07357909409023039&partnerID=40&md5=a40ab019560ee33f386b1f3c0adb9582
Notes:	Export Date: 14 January 2019 -- Article -- Source: Scopus

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