A positive feedback loop coordinates growth and patterning in the vertebrate limb Journal Article
| Authors: | Niswander, L.; Jeffrey, S.; Martin, G. R.; Tickle, C. |
| Article Title: | A positive feedback loop coordinates growth and patterning in the vertebrate limb |
| Abstract: | LIMB development depends on signals from the apical ectodermal ridge and underlying mesenchyme Fibroblast growth factor (FGF) can replace the ridgeand, because NA is localized to the mouse posterior ridge we proposed that FGF4 is the endogenous ridge signal Ridge signals control limb outgrowth and maintain the zone of polarizing activity (ZPA) at the limb posterior margin which is important in limb patterning: a ZPA graft to limb anterior mesenchyme causes cell respecification and mirror-image duplications Sonic hedgehog (SHH has polar-izing activity, and RNA. co-localizes with ZPA activity, suggesting SHH is the endogenous polarizing signal We have investigated the molecular regulation of and expression. We report here that expression in the ridge can be regulated byexpressing cells. Moreover, Shh expression in mesenchyme can be activated by FGF4 in combination with retinoic acid. Once induced, xpression can be maintained by FGF4 alone, thus establishing a positive feedback loop between ZPA and ridge. © 2002 Nature Publishing Group. |
| Keywords: | signal transduction; proto-oncogene proteins; nonhuman; proteins; mouse; animals; mice; embryo; animal experiment; hedgehog proteins; animalia; vertebrata; gene expression regulation; amino acid sequence; molecular sequence data; extremities; cell polarity; trans-activators; feedback; mesoderm; erinaceidae; polarization; fibroblast growth factor; fibroblast growth factors; cell transplantation; chick embryo; genes, homeobox; limb development; fibroblast growth factor 4; humans; priority journal; article |
| Journal Title: | Nature |
| Volume: | 371 |
| Issue: | 6498 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 1994-10-13 |
| Start Page: | 609 |
| End Page: | 612 |
| Language: | English |
| DOI: | 10.1038/371609a0 |
| PROVIDER: | scopus |
| PUBMED: | 7935794 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
