Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: Dorsal signals regulate anteroposterior patterning Journal Article
| Authors: | Yang, Y.; Niswander, L. |
| Article Title: | Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: Dorsal signals regulate anteroposterior patterning |
| Abstract: | Growth and patterning of the vertebrate limb are controlled by the ridge, posterior mesenchyme, and nonridge ectoderm. Fibroblast growth factor 4 (FGF4) and Sonic hedgehog (SHH) can mediate signaling from the ridge and posterior mesenchyme, respectively. Here we show that dorsal ectoderm is required together with FGF4 to maintain Shh expression. Removal of dorsal ectoderm results in loss of posterior skeletal elements, which can be rescued by exogenous SHH. Wnt7a, which is expressed in dorsal ectoderm, provides the signal required for Shh expression and formation of posterior structures. These results provide evidence that all three axes (dorsoventral, proximodistal, and anteroposterior) are intimately linked by the respective signals WNT7a, FGF4, and SHH during limb outgrowth and patterning. © 1995. |
| Keywords: | signal transduction; controlled study; proto-oncogene proteins; nonhuman; polymerase chain reaction; proteins; mouse; animal; mice; animal tissue; embryo; morphogenesis; gene expression regulation; molecular sequence data; extremities; base sequence; molecular interaction; dna primers; mesenchyme; fibroblast growth factor; fibroblast growth factors; chick embryo; ectoderm; limb development; embryonic induction; priority journal; article; support, u.s. gov't, p.h.s.; embryo and fetal development |
| Journal Title: | Cell |
| Volume: | 80 |
| Issue: | 6 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 1995-03-24 |
| Start Page: | 939 |
| End Page: | 947 |
| Language: | English |
| DOI: | 10.1016/0092-8674(95)90297-x |
| PUBMED: | 7697724 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
