Nuclear localization of anti-Hu antibody is not associated with in vitro cytotoxicity Journal Article
| Authors: | Hormigo, A.; Lieberman, F. |
| Article Title: | Nuclear localization of anti-Hu antibody is not associated with in vitro cytotoxicity |
| Abstract: | IgG fractions of sera containing anti-Hu antibodies or control sera were influenced with Hu-positive and Hu-negative cell lines. Anti-Hu IgG specifically localized in the nucleus of Hu-positive cells. Anti-Hu-positive and control sera were incubated with Hu-positive cells and human complement or peripheral blood mononuclear cells. Hu antibody caused neither complement-mediated lysis nor augmented antibody-dependent cell-mediated cytotoxicity. Anti-Hu IgG did not affect proliferation of Hu-positive cells. Anti-Hu antibodies may not play a direct role in tissue injury in patients with paraneoplastic encephalomyeloneuropathy and anti-Hu antibodies. © 1994. |
| Keywords: | immunohistochemistry; human cell; cell proliferation; cell division; sensory neuropathy; cell growth; cell line; nerve tissue proteins; cytotoxicity; tumor cells, cultured; rna-binding proteins; blotting, western; immunoglobulin g; immunocytochemistry; brain diseases; cytotoxicity, immunologic; lung carcinoma; cell nucleus; autoantibody; autoantibodies; antibody dependent cellular cytotoxicity; complement; encephalomyelitis; paraneoplastic syndromes; anti-hu antibody; human; priority journal; article; support, non-u.s. gov't; antibody internalization; paraneoplastic encephalomyeloneuropathy |
| Journal Title: | Journal of Neuroimmunology |
| Volume: | 55 |
| Issue: | 2 |
| ISSN: | 0165-5728 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1994-12-01 |
| Start Page: | 205 |
| End Page: | 212 |
| Language: | English |
| DOI: | 10.1016/0165-5728(94)90011-6 |
| PROVIDER: | scopus |
| PUBMED: | 7829670 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
