Mammalian cell survival studies characterizing multiport negative π-meson irradiation with the Stanford Medical Pion Generator (SMPG) Journal Article
| Authors: | Li, G. C.; Fessenden, P.; Hahn, G. M.; Fisher, G.; Luxton, G.; Bagshaw, M. A. |
| Article Title: | Mammalian cell survival studies characterizing multiport negative π-meson irradiation with the Stanford Medical Pion Generator (SMPG) |
| Abstract: | Radiobiological measurements have been made under various conditions of muliport pion irradiation using the Stanford Medical Pion Generator (SMPG). Chinese hamster cells (HA-1) were suspended in a tissue-equivalent 25% gelatin/medium solution. Hypoxic and aerobic HA-1 cells were irradiated simultaneously in a cylindrical water tank at either 4 or 16°C. Irradiation at the focus of 60 converging pion beams, at a peak dose rate of 6 rads/min, gave relative biological effectiveness (RBEs) of 2 8, 1 8 and 1 4 at 50, 20 and 5% survival, respectively, and an oxygen enhancement ratio (OER) of 1 7. Plateau irradiation with crossing pion beams, at a peak dose-rate of 3 rads/min, resulted in survival values very close to those obtained with similar doses of 85 kV X-rays. Preliminary studies with large irradiation volumes in broadened pion stopping regions indicate RBEs significantly > 1 for survival > 50% Supporting microdosimetric data with the SMPG are consistent with the radiobiological results. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
| Keywords: | nonhuman; conference paper; comparative study; radiation dose; neoplasms; animal cell; animal; cell survival; cell line; relative biological effectiveness; water; relative biologic effectiveness; mammal cell; cho cell; microdosimetry; gelatin; human; support, u.s. gov't, p.h.s.; hamsters; models, structural; oxygen enhancement ratio; negative pion irradiation; negative pion radiation; mesons |
| Journal Title: | International Journal of Hyperthermia |
| Volume: | 10 |
| Issue: | 3 |
| ISSN: | 0265-6736 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 1994-01-01 |
| Start Page: | 361 |
| End Page: | 370 |
| Language: | English |
| DOI: | 10.3109/02656739409010280 |
| PROVIDER: | scopus |
| PUBMED: | 7930802 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
