Tissue autofluorescence as an intermediate endpoint in NMBA-induced esophageal carcinogenesis Journal Article

  


Authors: Glasgold, R.; Glasgold, M.; Savage, H.; Pinto, J.; Alfano, R.; Schantz, S.
Article Title: Tissue autofluorescence as an intermediate endpoint in NMBA-induced esophageal carcinogenesis
Abstract: The capacity to identify subclinical neoplastic disease of the upper aerodigestive tract (UADT) using tissue autofluorescent spectroscopy would significantly contribute to cancer screening. Rats received N-nitrosomethyl benzylamine (NMBA), a carcinogen shown to cause esophageal malignancies. Following sacrifice at early weekly intervals, gross assessment of esophageal mucosa of NMBA-exposed rats was indistinguishable from saline-treated controls. Histopathologic evaluation, however, revealed NMBA-induced preneoplastic changes in the epithelium. Concurrent with these changes, the NMBA-exposed rats demonstrated specific alterations in autofluorescence. These results demonstrate that NMBA-induced esophageal premalignancy can be distinguished by autofluorescent properties. The capacity to detect alterations in autofluorescence may allow more sensitive screening of UADT mucosa at risk for cancer development. © 1994.
Keywords: controlled study; histopathology; carcinoma, squamous cell; nonhuman; animal; animal tissue; fluorescence; animal experiment; animal model; cancer screening; carcinogenesis; animalia; rat; fluorescence spectroscopy; rats; rats, sprague-dawley; esophagus cancer; esophageal neoplasms; carcinogen; precancerous conditions; carcinogens; spectrum analysis; precancer; autofluorescence; esophagus mucosa; priority journal; article; esophageal malignancy; n-nitrosomethyl benzylamine; preneoplastic changes; tissue autofluorescence; n benzyl n methylnitrosamine; dimethylnitrosamine
Journal Title: Cancer Letters
Volume: 82
Issue: 1
ISSN: 0304-3835
Publisher: Elsevier Ireland Ltd.  
Date Published: 1994-07-15
Start Page: 33
End Page: 41
Language: English
DOI: 10.1016/0304-3835(94)90143-0
PROVIDER: scopus
PUBMED: 8033066
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028358144&doi=10.1016%2f0304-3835%2894%2990143-0&partnerID=40&md5=048a6093dd375f9a8ab25f778ef2d756
Notes: Export Date: 14 January 2019 -- Article -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Stimson P Schantz
    115 Schantz
  2. Howard Savage
    29 Savage
  3. John Pinto
    59 Pinto
Related MSK Work