Guidelines of care for the management of primary cutaneous melanoma Journal Article


Authors: Swetter, S. M.; Tsao, H.; Bichakjian, C. K.; Curiel-Lewandrowski, C.; Elder, D. E.; Gershenwald, J. E.; Guild, V.; Grant-Kels, J. M.; Halpern, A. C.; Johnson, T. M.; Sober, A. J.; Thompson, J. A.; Wisco, O. J.; Wyatt, S.; Hu, S.; Lamina, T.
Article Title: Guidelines of care for the management of primary cutaneous melanoma
Abstract: The incidence of primary cutaneous melanoma continues to increase each year. Melanoma accounts for the majority of skin cancer-related deaths, but treatment is usually curative following early detection of disease. In this American Academy of Dermatology clinical practice guideline, updated treatment recommendations are provided for patients with primary cutaneous melanoma (American Joint Committee on Cancer stages 0-IIC and pathologic stage III by virtue of a positive sentinel lymph node biopsy). Biopsy techniques for a lesion that is clinically suggestive of melanoma are reviewed, as are recommendations for the histopathologic interpretation of cutaneous melanoma. The use of laboratory, molecular, and imaging tests is examined in the initial work-up of patients with newly diagnosed melanoma and for follow-up of asymptomatic patients. With regard to treatment of primary cutaneous melanoma, recommendations for surgical margins and the concepts of staged excision (including Mohs micrographic surgery) and nonsurgical treatments for melanoma in situ, lentigo maligna type (including topical imiquimod and radiation therapy), are updated. The role of sentinel lymph node biopsy as a staging technique for cutaneous melanoma is described, with recommendations for its use in clinical practice. Finally, current data regarding pregnancy and melanoma, genetic testing for familial melanoma, and management of dermatologic toxicities related to novel targeted agents and immunotherapies for patients with advanced disease are summarized. Published by Elsevier Inc.
Keywords: treatment; sentinel lymph node biopsy; melanoma; imiquimod; biopsy; pregnancy; radiation therapy; mohs micrographic surgery; genetic counseling; follow-up; surgical margins; staged excision; pathology report; skin toxicities; molecular techniques; nonsurgical techniques
Journal Title: Journal of the American Academy of Dermatology
Volume: 80
Issue: 1
ISSN: 0190-9622
Publisher: Mosby Elsevier  
Date Published: 2019-01-01
Start Page: 208
End Page: 250
Language: English
DOI: 10.1016/j.jaad.2018.08.055
PROVIDER: scopus c2 - 30392755
PUBMED: 30392755
DOI/URL:
Notes: J. Am. Acad. Dermatol. -- Export Date: 2 January 2019 -- Article -- Source: Scopus C2 - 30392755
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MSK Authors
  1. Allan C Halpern
    305 Halpern