Predictors of survival in patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery based on the pooled analysis of an international collaborative cohort Journal Article

   

Authors:	Zang, R. Y.; Harter, P.; Chi, D. S.; Sehouli, J.; Jiang, R.; Tropé, C. G.; Ayhan, A.; Cormio, G.; Xing, Y.; Wollschlaeger, K. M.; Braicu, E. I.; Rabbitt, C. A.; Oksefjell, H.; Tian, W. J.; Fotopoulou, C.; Pfisterer, J.; du Bois, A.; Berek, J. S.
Article Title:	Predictors of survival in patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery based on the pooled analysis of an international collaborative cohort
Abstract:	Background: This study aims to identify prognostic factors and to develop a risk model predicting survival in patients undergoing secondary cytoreductive surgery (SCR) for recurrent epithelial ovarian cancer. Methods: Individual data of 1100 patients with recurrent ovarian cancer of a progression-free interval at least 6 months who underwent SCR were pooled analysed. A simplified scoring system for each independent prognostic factor was developed according to its coefficient. Internal validation was performed to assess the discrimination of the model. Results: Complete SCR was strongly associated with the improvement of survival, with a median survival of 57.7 months, when compared with 27.0 months in those with residual disease of 0.1-1 cm and 15.6 months in those with residual disease of > 1 cm, respectively (P<0.0001). Progression-free interval (≤23.1 months vs >23.1 months, hazard ratio (HR): 1.72; score: 2), ascites at recurrence (present vs absent, HR: 1.27; score: 1), extent of recurrence (multiple vs localised disease, HR: 1.38; score: 1) as well as residual disease after SCR (R1 vs R0, HR: 1.90, score: 2; R2 vs R0, HR: 3.0, score: 4) entered into the risk model. Conclusion: This prognostic model may provide evidence to predict survival benefit from secondary cytoreduction in patients with recurrent ovarian cancer. © 2011 Cancer Research UK All rights reserved.
Keywords:	survival; adolescent; adult; cancer survival; treatment outcome; aged; aged, 80 and over; middle aged; survival rate; young adult; major clinical study; cancer recurrence; ascites; cancer risk; follow-up studies; endometrial neoplasms; neoplasm staging; ovarian cancer; cytoreductive surgery; ovarian neoplasms; ovary cancer; cohort studies; neoplasm recurrence, local; ovariectomy; adenocarcinoma, mucinous; cohort analysis; recurrence; scoring system; surgery; adenocarcinoma, clear cell; cystadenocarcinoma, serous; international agencies; pooled analysis
Journal Title:	British Journal of Cancer
Volume:	105
Issue:	7
ISSN:	0007-0920
Publisher:	Nature Publishing Group
Date Published:	2011-09-27
Start Page:	890
End Page:	896
Language:	English
DOI:	10.1038/bjc.2011.328
PROVIDER:	scopus
PMCID:	PMC3185944
PUBMED:	21878937
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-80053242297&partnerID=40&md5=a950f3a0314009f56839994f39da463a
Notes:	--- - "Export Date: 2 November 2011" - "CODEN: BJCAA" - "Source: Scopus"

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