Lobular carcinoma in situ Journal Article


Authors: Wen, H. Y.; Brogi, E.
Article Title: Lobular carcinoma in situ
Abstract: Lobular carcinoma in situ (LCIS) is a risk factor and a nonobligate precursor of breast carcinoma. The relative risk of invasive carcinoma after classic LCIS diagnosis is approximately 9 to 10 times that of the general population. Classic LCIS diagnosed on core biopsy with concordant imaging and pathologic findings does not mandate surgical excision, and margin status is not reported. The identification of variant LCIS in a needle core biopsy specimen mandates surgical excision, regardless of radiologic-pathologic concordance. The presence of variant LCIS close to the surgical margin of a resection specimen is reported, and reexcision should be considered. Copyright © 2017 Elsevier Inc. All rights reserved.
Keywords: pathology; diagnostic imaging; watchful waiting; partial mastectomy; disease management; mastectomy, segmental; e-cadherin; pleomorphic lobular carcinoma in situ; carcinoma, lobular; unnecessary procedures; precancerous conditions; unnecessary procedure; surgical margin; core biopsy; precancer; cdh1; lobular carcinoma; biopsy, large-core needle; large core needle biopsy; p120; humans; human; female; margins of excision; variant lobular carcinoma in situ; breast carcinoma in situ
Journal Title: Surgical Pathology Clinics
Volume: 11
Issue: 1
ISSN: 1875-9181
Publisher: Elsevier Inc.  
Date Published: 2018-03-01
Start Page: 123
End Page: 145
Language: English
DOI: 10.1016/j.path.2017.09.009
PUBMED: 29413653
PROVIDER: scopus
PMCID: PMC5841603
DOI/URL:
Notes: Review -- Export Date: 3 December 2018 -- Source: Scopus
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MSK Authors
  1. Yong Hannah Wen
    142 Wen
  2. Edi Brogi
    344 Brogi