IgG4-related kidney disease in a patient with history of breast cancer: Findings on (18)F-FDG PET/CT Journal Article


Authors: Krebs, S.; Monti, S.; Seshan, S.; Fox, J.; Mannelli, L.
Article Title: IgG4-related kidney disease in a patient with history of breast cancer: Findings on (18)F-FDG PET/CT
Abstract: A 64-year-old African American woman with history of stage III breast carcinoma, 3 years after complete response to therapy, presents with progressive fatigue, increasing arthralgia, and unintentional weight loss of 15 lb in 3 months. An F-FDG PET demonstrated new diffuse FDG avidity of the renal parenchyma, new FDG-avid foci in pancreas and lungs, and new FDG-avid lymph nodes above and below the diaphragm. While a retroperitoneal lymph node biopsy was inconclusive, a kidney biopsy resulted in diagnosis of diffuse, severe, IgG4-related tubulointerstitial nephritis. Treatment with corticosteroid led to complete resolution of the symptoms and PET findings.
Keywords: middle aged; case report; radiopharmaceuticals; diagnosis, differential; differential diagnosis; diagnostic imaging; breast neoplasms; immunology; immunoglobulin g; breast tumor; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; carcinoma; radiopharmaceutical agent; autoimmune diseases; autoimmune disease; nephritis; humans; human; female; positron emission tomography-computed tomography; positron emission tomography computed tomography
Journal Title: Clinical Nuclear Medicine
Volume: 41
Issue: 8
ISSN: 0363-9762
Publisher: Lippincott Williams & Wilkins  
Date Published: 2016-08-01
Start Page: e388
End Page: e389
Language: English
DOI: 10.1097/rlu.0000000000001252
PUBMED: 27187735
PROVIDER: scopus
PMCID: PMC4977093
DOI/URL:
Notes: Article -- Export Date: 3 December 2018 -- Source: Scopus
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  1. Josef J Fox
    71 Fox
  2. Simone Susanne Krebs
    55 Krebs