Reversible electroporation-mediated liposomal doxorubicin delivery to tumors can be monitored With (89)Zr-labeled reporter nanoparticles Journal Article

   

Authors:	Srimathveeravalli, G.; Abdel-Atti, D.; Pérez-Medina, C.; Takaki, H.; Solomon, S. B.; Mulder, W. J. M.; Reiner, T.
Article Title:	Reversible electroporation-mediated liposomal doxorubicin delivery to tumors can be monitored With (89)Zr-labeled reporter nanoparticles
Abstract:	Reversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal nanoparticle (89Zr-NRep) for monitoring RE-mediated liposomal doxorubicin (DOX) delivery in mouse tumors. Intravenously delivered 89Zr-NRep allowed positron emission tomography imaging of electroporation-mediated nanoparticle uptake. The relative order of 89Zr-NRep injection and electroporation did not result in significantly different overall tumor uptake, suggesting direct transfection and vascular permeability can independently mediate deposition of 89Zr-NRep in tumors. 89Zr-NRep and DOX uptake correlated well in both electroporated and control tumors at all experimental time points. Electroporation accelerated 89Zr-NRep and DOX deposition into tumors and increased DOX dosing. Reversible electroporation–related vascular effects seem to play an important role in nanoparticle delivery to tumors and drug uptake can be quantified with 89Zr-NRep. © The Author(s) 2018.
Keywords:	positron emission tomography; tumors; electroporation; nanoparticles; nanoparticle; liposomal doxorubicin; drug delivery; targeted drug delivery; animal pet; deposition; vascular permeability; controlled drug delivery; liposomal nanoparticles; nanoparticle uptakes; relative order; vascular effects
Journal Title:	Molecular Imaging
Volume:	17
ISSN:	1535-3508
Publisher:	Sage Publications, Inc.
Date Published:	2018-01-01
Language:	English
DOI:	10.1177/1536012117749726
PROVIDER:	scopus
PMCID:	PMC5833236
PUBMED:	29480077
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054848224&doi=10.1177%2f1536012117749726&partnerID=40&md5=6d2a0b8943d9fe5692f4eaa55839fcbd
Notes:	Article -- Export Date: 1 November 2018 -- Source: Scopus

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