Radiotherapy and regional nodes Book Section
| Authors: | Cahlon, O.; McCormick, B. |
| Editors: | Bland, K. I.; Copeland, E. M. 3rd; Klimberg, V. S.; Gradishar, W. J.; White, J.; Korourian, S. |
| Article/Chapter Title: | Radiotherapy and regional nodes |
| Abstract: | The importance of regional lymph nodes in breast cancer and their appropriate treatment has undergone dramatic changes in a relatively short period. Although oncologists once considered them the gold standard for patient prognosis and prediction of who may benefit from systemic therapy, they have now turned to tumor markers, breast cancer intrinsic subtypes, and the "score" from several available tumor gene sets, such as such as the Oncotype Score (Genomic Health), the Mammoprint, and others. As well, the century-old Halsted concept of the regional lymph nodes as the "next step" toward spread of cancer from the breast to the nodes and ultimately to distant sites has been replaced with other models, resulting in a marked change in the nodal surgery recommended for a woman with a new breast cancer diagnosis. These concept changes have had a major impact on the role of radiotherapy in the management of breast cancer, in addition to changes in surgical approach. As is clear from recent studies, these new paradigms are applicable to both women who choose breast conservation surgery and those who choose mastectomy. This chapter focuses on recent studies in patients with early-stage breast cancer and the interpretation of the results for radiation treatment planning after breast conservation surgery. © 2018 Elsevier Inc. All rights reserved. |
| Keywords: | breast conservation surgery; whole breast radiation; regional lymph node treatment |
| Book Title: | The Breast: Comprehensive Management of Benign and Malignant Diseases. 5th ed |
| ISBN: | 978-0-323-35955-9 |
| Publisher: | Elsevier Inc. |
| Publication Place: | Philadelphia, PA |
| Date Published: | 2018-01-01 |
| Start Page: | 677 |
| End Page: | 688.e2 |
| Language: | English |
| DOI: | 10.1016/b978-0-323-35955-9.00048-9 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 48 -- Export Date: 1 November 2018 -- Source: Scopus |
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