The evolving role of axillary lymph node dissection in the modern era of breast cancer management Journal Article

  


Authors: Barry, J. M.; Weber, W. P.; Sacchini, V.
Article Title: The evolving role of axillary lymph node dissection in the modern era of breast cancer management
Abstract: The standard of practice in breast cancer surgery is that all patients with a positive sentinel node mandate an axillary lymph node dissection (ALND). Recently, this dogma has been challenged by a trial from ACOSOG (American College Of Surgeons Oncology Group) (Trial Z0011) which demonstrated that patients (without clinically/radiologically apparent axillary metastases) undergoing breast conserving surgery (i.e lumpectomy followed by whole breast radiotherapy) with positive sentinel nodes failed to derive any significant benefit by having an axillary lymph node dissection (ALND) [2]. The logical progression from this study is to question the validity of performing routine axillary lymph node dissections on all patients with positive sentinel lymph nodes (SLN). In addition to the Z0011 trial, there is emerging data that additional patients exist who fail to derive any benefit from axillary surgery. The aim of this article is to discuss the potential subpopulations of patients that may avoid unnecessary ALND in the modern era of breast cancer management. © 2010 Elsevier Ltd. All rights reserved.
Keywords: immunohistochemistry; cancer chemotherapy; cancer survival; review; cancer radiotherapy; postoperative care; preoperative care; positron emission tomography; follow up; lymph node metastasis; lymph node dissection; diagnostic accuracy; sentinel lymph node; breast cancer; partial mastectomy; micrometastasis; tamoxifen; eosin; hematoxylin; axillary lymph node extirpation; aspiration biopsy; axillary lymph node dissection; cancer prognosis; positive sentinel lymph node management; z0011 trial
Journal Title: Surgical Oncology
Volume: 21
Issue: 2
ISSN: 0960-7404
Publisher: Elsevier Inc.  
Date Published: 2012-06-01
Start Page: 143
End Page: 145
Language: English
DOI: 10.1016/j.suronc.2011.02.004
PROVIDER: scopus
PUBMED: 21440434
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84860330496&partnerID=40&md5=d22cc66a1f50117825d8f9314f11119b
Notes: --- - "Export Date: 4 June 2012" - "CODEN: SUOCE" - "Source: Scopus"
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MSK Authors
  1. Walter Paul Weber
    4 Weber
  2. Virgilio Sacchini
    149 Sacchini
  3. John Mitchel Barry
    9 Barry
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