Influence of contrast administration on computed tomography–based analysis of visceral adipose and skeletal muscle tissue in clear cell renal cell carcinoma Journal Article
| Authors: | Paris, M. T.; Furberg, H. F.; Petruzella, S.; Akin, O.; Hötker, A. M.; Mourtzakis, M. |
| Article Title: | Influence of contrast administration on computed tomography–based analysis of visceral adipose and skeletal muscle tissue in clear cell renal cell carcinoma |
| Abstract: | Background: Computed tomography (CT) scans are being utilized to examine the influence of skeletal muscle and visceral adipose quantity and quality on health-related outcomes in clinical populations. However, little is known about the influence of contrast administration on these parameters. Methods: Precontrast, arterial, and 3-minute postcontrast CT images of 45 patients with clear cell renal cell carcinoma were downloaded from The Cancer Imaging Archive and retrospectively analyzed for visceral adipose cross-sectional area (CSA) and density, and muscle CSA and density at the third lumbar vertebrae. Low muscle CSA index was defined as ≤38.9 cm2/m2 for women and ≤55.4 cm2/m2 for men. Low muscle density was defined as <41 Hounsfield units (HU) for body mass index (BMI) <24.9 kg/m2 and <33 HU for BMI ≥25.0 kg/m2. Results: In both the arterial and 3-minute phases, contrast administration decreased visceral adipose CSA (−20.9 and −20.9 cm2; P <.001) and increased visceral adipose density (4.8 and 5.8 HU; P <.001), relative to precontrast images. Muscle CSA index marginally increased in the arterial (0.6 cm2/m2; P =.007) and 3-minute phases (0.8 cm2/m2; P <.001). This likely represents clinically insignificant changes because it does not alter the identification of low muscle CSA (44.4% vs 42.2%; P = 1.00). Skeletal muscle density increased in the arterial (6.4 HU; P <.001) and 3-minute phases (8.7 HU; P <.001), which altered the identification of low muscle density (6.7% vs 31.1%; P <.001). Conclusions: Future analyses should consider the phase of contrast during CT imaging because it may alter the interpretations of several parameters. © 2018 American Society for Parenteral and Enteral Nutrition |
| Keywords: | body composition; computed tomography; sarcopenia; visceral adipose; muscle quality |
| Journal Title: | Journal of Parenteral and Enteral Nutrition |
| Volume: | 42 |
| Issue: | 7 |
| ISSN: | 0148-6071 |
| Publisher: | Sage Publications |
| Date Published: | 2018-09-01 |
| Start Page: | 1148 |
| End Page: | 1155 |
| Language: | English |
| DOI: | 10.1002/jpen.1067 |
| PROVIDER: | scopus |
| PUBMED: | 29350403 |
| PMCID: | PMC7645806 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 October 2018 -- Source: Scopus |
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22Hoetker
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