Influence of contrast administration on computed tomography–based analysis of visceral adipose and skeletal muscle tissue in clear cell renal cell carcinoma Journal Article


Authors: Paris, M. T.; Furberg, H. F.; Petruzella, S.; Akin, O.; Hötker, A. M.; Mourtzakis, M.
Article Title: Influence of contrast administration on computed tomography–based analysis of visceral adipose and skeletal muscle tissue in clear cell renal cell carcinoma
Abstract: Background: Computed tomography (CT) scans are being utilized to examine the influence of skeletal muscle and visceral adipose quantity and quality on health-related outcomes in clinical populations. However, little is known about the influence of contrast administration on these parameters. Methods: Precontrast, arterial, and 3-minute postcontrast CT images of 45 patients with clear cell renal cell carcinoma were downloaded from The Cancer Imaging Archive and retrospectively analyzed for visceral adipose cross-sectional area (CSA) and density, and muscle CSA and density at the third lumbar vertebrae. Low muscle CSA index was defined as ≤38.9 cm2/m2 for women and ≤55.4 cm2/m2 for men. Low muscle density was defined as <41 Hounsfield units (HU) for body mass index (BMI) <24.9 kg/m2 and <33 HU for BMI ≥25.0 kg/m2. Results: In both the arterial and 3-minute phases, contrast administration decreased visceral adipose CSA (−20.9 and −20.9 cm2; P <.001) and increased visceral adipose density (4.8 and 5.8 HU; P <.001), relative to precontrast images. Muscle CSA index marginally increased in the arterial (0.6 cm2/m2; P =.007) and 3-minute phases (0.8 cm2/m2; P <.001). This likely represents clinically insignificant changes because it does not alter the identification of low muscle CSA (44.4% vs 42.2%; P = 1.00). Skeletal muscle density increased in the arterial (6.4 HU; P <.001) and 3-minute phases (8.7 HU; P <.001), which altered the identification of low muscle density (6.7% vs 31.1%; P <.001). Conclusions: Future analyses should consider the phase of contrast during CT imaging because it may alter the interpretations of several parameters. © 2018 American Society for Parenteral and Enteral Nutrition
Keywords: body composition; computed tomography; sarcopenia; visceral adipose; muscle quality
Journal Title: Journal of Parenteral and Enteral Nutrition
Volume: 42
Issue: 7
ISSN: 0148-6071
Publisher: Sage Publications  
Date Published: 2018-09-01
Start Page: 1148
End Page: 1155
Language: English
DOI: 10.1002/jpen.1067
PROVIDER: scopus
PUBMED: 29350403
DOI/URL:
Notes: Article -- Export Date: 5 October 2018 -- Source: Scopus
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MSK Authors
  1. Oguz Akin
    176 Akin
  2. Andreas Markus Hoetker
    20 Hoetker