Late effects and survivorship issues in patients with neuroblastoma Journal Article

Authors: Novetsky Friedman, D.; Henderson, T. O.
Article Title: Late effects and survivorship issues in patients with neuroblastoma
Abstract: Over the past two decades, marked progress has been made in understanding the biology of neuroblastoma; this has led to refined risk stratification and treatment modifications with resultant increasing 5-year survival rates for children with neuroblastoma. Survivors, however, remain at risk for a wide variety of potential treatment-related complications, or late effects, which may lead to excess morbidity and premature mortality in this cohort. This review summarizes the existing survivorship literature on long-term health outcomes for survivors of neuroblastoma, focusing specifically on potential injury to the endocrine, sensory, cardiovascular, pulmonary, and renal systems, as well as survivors' treatment-related risk for subsequent neoplasms and impaired quality of life. Additional work is needed to assess the potential late effects of newer multimodality therapies with the aim of optimizing long-term medical and psychosocial outcomes for all survivors of neuroblastoma.
Keywords: childhood cancer; late effects; neuroblastoma; irradiation; survivorship; long-term survivors; stem-cell transplantation; quality-of-life; total-body; bone-marrow-transplantation; high-risk neuroblastoma; nodular hyperplasia; focal; childrens-oncology-group; intensive induction chemotherapy; childhood-cancer-survivor
Journal Title: Children
Volume: 5
Issue: 8
ISSN: 2227-9067
Publisher: MDPI  
Date Published: 2018-08-01
Start Page: 107
Language: English
ACCESSION: WOS:000443248700007
DOI: 10.3390/children5080107
PMCID: PMC6111874
PUBMED: 30082653
Notes: Review -- 107 -- Source: Wos
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