Somatostatin-receptor imaging in lymphoma Journal Article

  


Authors: Goldsmith, S. J.; Macapinlac, H. A.; O'Brien, J. P.
Article Title: Somatostatin-receptor imaging in lymphoma
Abstract: Patients with Hodgkin's or non-Hodgkin's lymphoma are staged for treatment based on the extent of known disease, involvement and the histopathologic grading of the disease. Radiological techniques, including computed tomography, usually depend on estimates of lymph node enlargement and mass effects as the criterion for disease involvement. Lymphomatous tissue obtained at surgery has shown high-density somatostatin receptors. Several groups have evaluated the utility of 111In-DTPA-pentetreotide (Octreoscan, Mallinckrodt, St. Louis, MO) to detect lymphomatous tissue for more accurate staging of patients with lymphoma. The procedure is safe; both Hodgkin's and non-Hodgkins disease involvement is identified. The results, however, have not been uniformly predictive of disease involvement. Consequently, the routine use of this technique in place of currently used anatomic imaging methods is not recommended at this time. The significance of detecting somatostatin receptors in vivo in patients with malignant lymphoma requires further study. © 1995 W.B. Saunders Company.
Keywords: adult; sensitivity and specificity; hodgkin disease; indium radioisotopes; nonhodgkin lymphoma; diagnostic agent; lymphoma, non-hodgkin; prediction and forecasting; predictive value of tests; drug derivative; scintiscanning; octreotide; somatostatin receptor; middle age; pentetic acid; indium; human; male; female; article; receptors, somatostatin; sdz 215 811; sdz 215-811
Journal Title: Seminars in Nuclear Medicine
Volume: 25
Issue: 3
ISSN: 0001-2998
Publisher: Elsevier Inc.  
Date Published: 1995-07-01
Start Page: 262
End Page: 271
Language: English
DOI: 10.1016/s0001-2998(95)80015-8
PUBMED: 7570045
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029328586&doi=10.1016%2fS0001-2998%2895%2980015-8&partnerID=40&md5=c7ca3c0032dec3f39bf7ed7c400f3dbc
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
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MSK Authors
  1. James O'Brien
    28 O'Brien
  2. Homer Macapinlac
    106 Macapinlac
  3. Stanley J. Goldsmith
    30 Goldsmith
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