Designer cytokines: Targeting actions to cells of choice Journal Article
| Authors: | Economides, A. N.; Ravetch, J. V.; Yancopoulos, G. D.; Stahl, N. |
| Article Title: | Designer cytokines: Targeting actions to cells of choice |
| Abstract: | Some growth factors are therapeutically useful partly because restricted expression of their receptors limits their action to particular cell types. However, no unique stimulatory factor is known for many clinically relevant cell types, such as CD34+ hematopoietic stem cells. Here, soluble α receptor (Ra) components for interleukin-6 (IL-6) and ciliary neurotrophic factor (CNTF) were targeted in an active form to cells expressing surface markers such as CD34 or CD45, thereby rendering those cells responsive to IL-6 or CNTF. The targeting of Ra components may provide the means to create "designer" cytokines that activate a desired cell type expressing a specific cell surface marker. |
| Keywords: | animal; cell division; cd34 antigen; cell line; nerve tissue proteins; tumor cells, cultured; phosphorylation; cell type; cytokine; antibodies, monoclonal; membrane glycoproteins; cell surface marker; cell membrane; interleukin 6; interleukin-6; hematopoietic stem cell; antigens, cd; antigens, cd34; cd45 antigen; solubility; antigens, cd45; receptors, nerve growth factor; interleukin receptor; receptors, fc; receptors, cytokine; receptors, interleukin-6; receptors, interleukin; human; priority journal; article; ciliary neurotrophic factor; chimeric proteins; receptor, ciliary neurotrophic factor; immunoglobulins, fc |
| Journal Title: | Science |
| Volume: | 270 |
| Issue: | 5240 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 1995-11-24 |
| Start Page: | 1351 |
| End Page: | 1353 |
| Language: | English |
| DOI: | 10.1126/science.270.5240.1351 |
| PUBMED: | 7481821 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
