Dextromethorphan suppresses both formalin-induced nociceptive behavior and the formalin-induced increase in spinal cord c-fos mRNA Journal Article
| Authors: | Elliott, K. J.; Brodsky, M.; Hynansky, A. D.; Foley, K. M.; Inturrisi, C. E. |
| Article Title: | Dextromethorphan suppresses both formalin-induced nociceptive behavior and the formalin-induced increase in spinal cord c-fos mRNA |
| Abstract: | The injection of dilute formalin results in a stereotyped nociceptive behavioral response. Administration of dextromethorphan (s.c.) but not saline, 30 min prior to intraplantar formalin injection prevents this nociceptive response in a dose-dependent manner. In addition, intraplantar formalin reliably induces c fos mRNA in the ipsilateral spinal dorsal horn as assessed with quantitative solution hybridization at 30 min postinjection. No change in c-fos mRNA was detected in the contralateral spinal dorsal horn, nucleus raphe magnus, periaqueductal grey, medial thalamus, or sensorimotor cortex. Pretreatment with dextromethorphan at 60 mg/ kg s.c., 30 min prior to formalin resulted in a suppression of c fos induction, so that c fos mRNA levels in the ipsilateral spinal dorsal horn of animals receiving dextromethorphan prior to formalin did not differ from controls. These data indicate that dextromethorphan suppresses formalin nociceptive behavior and one of the biochemical consequences of formalin nociception, i.e., induction of c-fos mRNA. © 1995. |
| Keywords: | controlled study; nonhuman; comparative study; mouse; animal; mice; pain; animal experiment; animal model; mice, inbred balb c; messenger rna; rna, messenger; spinal cord; behavior; formaldehyde; behavior, animal; n methyl dextro aspartic acid receptor; antinociception; protein c fos; proto-oncogene proteins c-fos; subcutaneous drug administration; male; priority journal; article; immediate early gene; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; dextromethorphan; formalin; depression, chemical; solution hybridization; c-fos mrna; immediateearly gene; nmda receptor antagonist; spinal dorsal horn |
| Journal Title: | Pain |
| Volume: | 61 |
| Issue: | 3 |
| ISSN: | 0304-3959 |
| Publisher: | Elsevier Science BV |
| Date Published: | 1995-06-01 |
| Start Page: | 401 |
| End Page: | 409 |
| Language: | English |
| DOI: | 10.1016/0304-3959(94)00214-y |
| PUBMED: | 7478683 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
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