| Abstract: |
The receptor mechanisms mediating the retrograde axonal transport of the neurotrophins have been investigated in adult rats. We show that transport of the TrkB ligands NT-4 and BDNF to peripheral neurons is dependent on the low affinity neurotrophin receptor (LNR). Pharmacological manipulation of LNR in vivo using either an anti-LNR antibody or a soluble recombinant LNR extracellular domain completely blocked retrograde transport of NT-4 and BDNF to sensory neurons, while having minimal effects on the transport of NGF in either sensory or sympathetic neurons. Furthermore, in mice with a null mutation of LNR, the transport of NT-4 and BDNF, but not NGF, was dramatically reduced. These observations demonstrate a selective role for LNR in retrograde transport of the various neurotrophins from distinct target regions in vivo. © 1995. |
| Keywords: |
mutation; nonhuman; animal cell; animal; mice; animal tissue; animal experiment; nerve tissue proteins; nerve growth factors; mice, inbred balb c; brain derived neurotrophic factor; brain-derived neurotrophic factor; motor neurons; rat; binding sites; rats; receptor protein-tyrosine kinases; rats, sprague-dawley; neurons, afferent; ligand binding; dissociation; biological transport; sensory nerve cell; receptor, nerve growth factor; receptors, nerve growth factor; ganglia, spinal; cell receptor; nerve growth factor; trigeminal nerve; nerve fiber transport; human; male; priority journal; article; wheat germ agglutinins; neurotropin; axonal transport; receptor, ciliary neurotrophic factor; receptors, neuropeptide
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