BCL6 gene rearrangement and other cytogenetic abnormalities in diffuse large cell lymphoma Journal Article


Authors: Offit, K.; Louie, D. C.; Parsa, N. Z.; Roy, P.; Leung, D.; Lo Coco, F.; Zelenetz, A.; Dalla-Favera, R.; Chaganti, R. S. K.
Article Title: BCL6 gene rearrangement and other cytogenetic abnormalities in diffuse large cell lymphoma
Abstract: Evidence for rearrangement of the BCL6 gene at 3q27 has been documented in 20-30% of diffuse lymphomas with a large cell component (DLLC), and was found to be of prognostic significance at the time of diagnosis. To incorporate these observations into current cytogenetic and clinical prognostic models, 76 cases of DLLC with known BCL6 status were analyzed. Cytogenetic indicators of progression, including trisomy 7, trisomy 12, del(6)(q21q25), and structural alterations of 17p were less frequent in BCL6 rearranged DLLC compared to BCL6 germline tumors. Despite a 93% overall survival at median follow-up of 30 months, a trend for continued relapse resulted in a projected freedom from progression for the BCL6 rearranged cohort of 66% at 4 years, compared to 39% for the BCL6 germline cohort. Six cases among the BCL6 rearranged group lacked additional cytogenetic indicators of progression and remained free of disease at follow-up in excess of 7 years, whereas BCL6 rearranged cases with increasing numbers of cytogenetic aberrations showed decreased intervals free from progression of disease. These results suggest that BCL6 rearrangement should be combined with other known clinical and cytogenetic indicators in prognostic analyses of patients with DLLC. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Keywords: major clinical study; dna-binding proteins; proto-oncogene proteins; cancer recurrence; cytogenetics; transcription factors; oncogene; gene rearrangement; non-hodgkin's lymphoma; disease progression; large cell lymphoma; chromosome aberrations; chromosome deletion; chromosome mapping; chromosome 3; chromosomes, human, pair 3; zinc fingers; proto-oncogenes; trisomy; proto-oncogene proteins c-bcl-6; lymphoma, large-cell, diffuse; chromosome disorders; humans; prognosis; human; priority journal; article; interstitial chromosome deletion
Journal Title: Leukemia and Lymphoma
Volume: 20
Issue: 1-2
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 1995-12-01
Start Page: 85
End Page: 89
Language: English
DOI: 10.3109/10428199509054757
PUBMED: 8750627
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Kenneth Offit
    509 Offit
  2. Diane C Louie
    47 Louie
  3. Denis Heng Yan Leung
    112 Leung
  4. Andrew D Zelenetz
    550 Zelenetz
  5. Raju S K Chaganti
    262 Chaganti
  6. Pampa Roy
    32 Roy