| Abstract: |
The immune system can recognize differentiation antigens that are selectively expressed on malignant cells and their normal cell counterparts. However, it is uncertain whether immunity to differentiation antigens can effectively lead to tumor rejection. The mouse brown locus protein, gp75 or tyrosinase-related protein 1, is a melanocyte differentiation antigen expressed by melanomas and normal melanocytes. The gp75 antigen is recognized by autoantibodies and autoreactive T cells in persons with melanoma. To model autoimmunity against a melanocyte differentiation antigen, mouse antibodies against gp75 were passively transferred into tumorbearing mice. Passive immunization with a mouse monoclonal antibody against gp75 induced protection and rejection of both subcutaneous tumors and lung metastases in syngeneic C57BL/6 mice, including established tumors. Passive immunity produced coat color alterations but only in regenerating hairs. This system provides a model for autoimmune vitiligo and shows that immune responses to melanocyte differentiation antigens can influence mouse coat color. Immune recognition of a melanocyte differentiation antigen can reject tumors, providing a basis for targeting tissue autoantigens expressed on cancer. © 1995, Rockefeller University Press., All rights reserved. |
| Keywords: |
controlled study; unclassified drug; dose response; nonhuman; animal cell; mouse; animal; mice; melanoma; skin neoplasms; melanocyte; melanocytes; lung neoplasms; neoplasm proteins; animal experiment; animal model; mice, inbred c57bl; monoclonal antibody; hair color; antibodies, monoclonal; antigens, neoplasm; membrane glycoproteins; antigen recognition; melanoma cell; melanoma, experimental; neoplasms, experimental; autoantigen; autoantigens; killer cells, natural; autoimmunity; graft rejection; neoplasm transplantation; tyrosinase related protein 1; tumor rejection; immunotherapy, adoptive; differentiation antigen; vitiligo; passive immunization; monoclonal antibody ta99; intraperitoneal drug administration; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; glycoprotein gp 75
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