Does endotoxin stimulate cells by mimicking ceramide? Journal Article
| Authors: | Wright, S. D.; Kolesnick, R. N. |
| Article Title: | Does endotoxin stimulate cells by mimicking ceramide? |
| Abstract: | Recent studies indicate that tumor necrosis factor (TNF) and interleukin 1 (1L-1) stimulate cells via the intracellular messenger ceramide. Bacterial endotoxin (lipopolysaccharide; LPS) shows strong structural and functional resemblance to ceramide. Here, Samuel Wright and Richard Kolesnick review data suggesting that LPS may provoke cellular responses by mimicking the action of ceramide. © 1995 Elsevier Science Ltd. |
| Keywords: | signal transduction; review; animal; enzyme activation; structure-activity relationship; phosphorylation; gene expression regulation; cytokines; molecular sequence data; protein processing, post-translational; protein-serine-threonine kinases; carrier proteins; models, molecular; antigens, cd; molecular conformation; carbohydrate sequence; tumor necrosis factor; ceramide; ceramides; antigens, differentiation, myelomonocytic; interleukin 1; antigens, cd14; sphingomyelin; cytokine receptor; lipopolysaccharides; molecular mimicry; endotoxin; sphingomyelins; endotoxins; human; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Immunology Today |
| Volume: | 16 |
| Issue: | 6 |
| ISSN: | 0167-5699 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1995-06-01 |
| Start Page: | 297 |
| End Page: | 302 |
| Language: | English |
| DOI: | 10.1016/0167-5699(95)80185-5 |
| PUBMED: | 7544978 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
