Localization and physical mapping of the prostate-specific membrane antigen (PSM) gene to human chromosome 11 Journal Article

  

Authors:	Rinker-Schaeffer, C. W.; Hawkins, A. L.; Su, S. L.; Israeli, R. S.; Griffin, C. A.; Isaacs, J. T.; Heston, W. D. W.
Article Title:	Localization and physical mapping of the prostate-specific membrane antigen (PSM) gene to human chromosome 11
Abstract:	The prostate-specific membrane antigen (PSM) was identified by the monoclonal antibody 7E11-C5.3, which was raised against the human prostatic carcinoma cell line LNCaP (3). The PSM antigen is expressed by normal, neoplastic, and metastatic prostatic tissues. The 2.65-kb cDNA encoding the 100-kDa PSM glycoprotein was cloned from LNCaP cells (4). Studies have shown that the expression of PSM is tissue-specific (5). In the present study monochromosomal somatic cell hybrids were used to localize the PSM gene to human chromosome 11. Using this information, initial mapping studies identified two potential PSM gene loci at 11p11.1-p13 and 11q14. Further high-stringency analysis using cosmid probes identified the 11q14 region as the location of the PSM gene. © 1995 Academic Press. All rights reserved.
Keywords:	human cell; prostate specific antigen; in situ hybridization, fluorescence; gene expression; cancer cell culture; prostate cancer; gene mapping; antigens, neoplasm; chromosome analysis; chromosomes, human, pair 11; chromosome 11q; gene location; antigens, surface; chromosomal localization; chromosome mapping; chromosome 11p; hybrid cell; hybrid cells; blotting, southern; human; male; priority journal; article; support, u.s. gov't, p.h.s.
Journal Title:	Genomics
Volume:	30
Issue:	1
ISSN:	0888-7543
Publisher:	Elsevier Inc.
Date Published:	1995-11-01
Start Page:	105
End Page:	108
Language:	English
DOI:	10.1006/geno.1995.0019
PUBMED:	8595888
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028851577&doi=10.1006%2fgeno.1995.0019&partnerID=40&md5=656a808755439bf6f553963e6219bfad
Notes:	Article -- Export Date: 28 August 2018 -- Source: Scopus

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