p53 nuclear overexpression may not be an independent prognostic marker in early colorectal cancer Journal Article
| Authors: | Grewal, H.; Guillem, J. G.; Klimstra, D. S.; Cohen, A. M. |
| Article Title: | p53 nuclear overexpression may not be an independent prognostic marker in early colorectal cancer |
| Abstract: | PURPOSE: This study was designed to determine if p53 nuclear overexpression, as detected by immunohistochemistry, is a marker of prognostic significance in early (Stage I) colorectal cancer (CRC). METHODS: Tissue sections obtained from archival blocks of 66 patients with surgically treated Stage 1 CRC were stained immunohistochemically for p53 using a monoclonal antibody (PAB 1801-Ab2). Differences in survival between p53 positive (p53+) and p53 negative (p53-) groups were compared using Kaplan-Meier survival curves and the log-rank test. RESULTS: Thirtyfour patients (51.5 percent) were p53+ and 32 (48.5 percent) were p53-. There were significantly more p53+ tumors in females (23 of 34) compared with males (11 of 34) (P=0.01). Follow-up ranged from 1 to 128.5 (mean, 44.7; median, 38.2) months. Thirteen patients (197 percent) developed recurrence, of whom five died of disease. Univariate analysis of clinical and pathologic variables did not reveal any statistically significant differences between p53+ and p53- tumors. Mean actuarial survival was longer (48.2 months) in the p53- group compared with the p53+ group (41.5 months). However, comparison of survival curves using the log-rank test did not show a statistically significant difference in survival (log-rank chi-squared=0.2;P=0.6). CONCLUSION: p53 nuclear overexpression does not appear to be an independent marker of prognostic significance in surgically treated early CRC. Females were more likely to have p53+ tumors. The biologic significance of this finding is unknown. © 1995 American Society of Colon and Rectal Surgeons. |
| Keywords: | immunohistochemistry; adult; cancer survival; clinical article; aged; survival analysis; cancer staging; colorectal cancer; antigen expression; tumor markers, biological; tumor biopsy; protein p53; colorectal neoplasms; immunoenzyme techniques; diagnostic value; antigen detection; prognosis; human; male; female; article; p53 nuclear overexpression; support, non-u.s. gov't |
| Journal Title: | Diseases of the Colon and Rectum |
| Volume: | 38 |
| Issue: | 11 |
| ISSN: | 0012-3706 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1995-11-01 |
| Start Page: | 1176 |
| End Page: | 1181 |
| Language: | English |
| DOI: | 10.1007/bf02048333 |
| PUBMED: | 7587760 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
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