Anorectal melanoma: A 64-year experience at Memorial Sloan-Kettering Cancer Center Journal Article
| Authors: | Brady, M. S.; Kavolius, J. P.; Quan, S. H. Q. |
| Article Title: | Anorectal melanoma: A 64-year experience at Memorial Sloan-Kettering Cancer Center |
| Abstract: | PURPOSE: Operative management of patients with anorectal melanoma is controversial. To formulate a rational approach to patients with this disease, we reviewed our experience from 1929 to 1993. METHODS: Records of all patients treated at our center with anorectal melanoma from 1929 to the present were reviewed. Survival analyses were graphically displayed using the Kaplan-Meier productlimit method, and distributions were compared using the log-rank test. Fisher's exact test was used to compare groups with small sample sizes. RESULTS: Survival for the entire group (n = 85) was poor, 17 percent at 5 years (median, 19 months). Among the 71 patients with resectable disease, the five-year, disease-free survival distribution of patients who underwent abdominoperineal resection (APR) was more favorable than that of patients who underwent local procedures only, although this was not statistically significant (27 percent vs. 5 percent, APRvs. local procedures, respectively;P=0.11). However, those who had an APR were more likely to survive long term than those who did not (P<0.05). All ten long-term survivors were women. Nine had undergone APR, and one had a wide local excision. Of the nine survivors following APR, eight had negative and one had positive mesenteric nodes. Median size of the primary tumor in survivors following APR was 2.5 cm, compared with 4.0 cm for patients who did not survive long term following APR. CONCLUSIONS: APR should be considered in patients with localized anorectal melanoma, particularly those with smaller tumors and no evidence of nodal metastases. © 1995 American Society of Colon and Rectal Surgeons. |
| Keywords: | adult; cancer survival; aged; aged, 80 and over; disease-free survival; survival rate; treatment failure; major clinical study; cancer recurrence; combined modality therapy; follow-up studies; lymph node metastasis; lymphatic metastasis; melanoma; neoplasm recurrence, local; sex difference; inguinal lymph node; rectal neoplasms; rectum abdominoperineal resection; abdominoperineal resection; middle age; anus neoplasms; anus tumor; anorectal melanoma; rectal melanoma; prognosis; human; male; female; article; support, non-u.s. gov't; anal melanoma |
| Journal Title: | Diseases of the Colon and Rectum |
| Volume: | 38 |
| Issue: | 2 |
| ISSN: | 0012-3706 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1995-02-01 |
| Start Page: | 146 |
| End Page: | 151 |
| Language: | English |
| DOI: | 10.1007/bf02052442 |
| PUBMED: | 7851168 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
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