Mammalian antiproliferative signals and their targets Journal Article
| Authors: | Massagué, J.; Polyak, K. |
| Article Title: | Mammalian antiproliferative signals and their targets |
| Abstract: | The effect of mitogens on the mammalian cell cycle is opposed by the action of antimitogens, such as TGF-β, CAMP agonists, and various anti proliferative drugs. The recent identification of TGF-β receptors that initiate antimitogenic signals and of cell cycle kinase inhibitors that respond to these signals has provided new insights into this process. The evidence argues that mitogenic and antimitogenic signals confront each other by regulating in opposite ways the activity of cyclin-dependent kinases that control cell commitment to DNA replication. © 1995. |
| Keywords: | signal transduction; gene mutation; review; cytotoxic agent; nonhuman; dna replication; protein domain; cell proliferation; animal; cell cycle; enzyme inhibition; transforming growth factor beta; protein binding; enzyme activity; amino acid sequence; transforming growth factor beta receptor; receptors, transforming growth factor beta; cycline; cyclin-dependent kinases; phosphotransferase; cell cycle g1 phase; g1 phase; genes, tumor suppressor; mammal cell; mitogenic agent; mitogens; human; priority journal; cyclic amp derivative |
| Journal Title: | Current Opinion in Genetics and Development |
| Volume: | 5 |
| Issue: | 1 |
| ISSN: | 0959-437X |
| Publisher: | Elsevier Inc. |
| Date Published: | 1995-02-01 |
| Start Page: | 91 |
| End Page: | 96 |
| Language: | English |
| DOI: | 10.1016/s0959-437x(95)90059-4 |
| PUBMED: | 7749332 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
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