IκB-β regulates the persistent response in a biphasic activation of NF-κB Journal Article


Authors: Thompson, J. E.; Phillips, R. J.; Erdjument-Bromage, H.; Tempst, P.; Ghosh, S.
Article Title: IκB-β regulates the persistent response in a biphasic activation of NF-κB
Abstract: We have cloned the cDNA encoding IκB-β, one of the two major IκB isoforms in mammalian cells. The recombinant IκB-β protein interacts with equal affinity to p65 and c-Rel and does not exhibit a preference between these Rel proteins. Instead the primary difference between IκB-α and IκB-β is in their response to different inducers of NF-κB activity. One class of inducers causes rapid but transient activation of NF-κB by primarily affecting IκB-α complexes, whereas another class of inducers causes persistent activation of NF-κB by affecting both IκB-α and IκB-β complexes. Therefore, the overall activation of NF-κB consists of two overlapping phases, a transient phase mediated through IκB-α and a persistent phase mediated through IκB-β. © 1995.
Keywords: protein phosphorylation; sequence analysis; dna-binding proteins; proto-oncogene proteins; nonhuman; comparative study; animal cell; animal; mammalia; mice; transcription initiation; protein binding; transcription factor; embryo development; immunoglobulin enhancer binding protein; gene expression regulation; molecular cloning; cloning, molecular; regulatory mechanism; amino acid sequence; molecular sequence data; sequence homology, amino acid; nf-kappa b; lung; dna, complementary; mammal cell; rabbits; proto-oncogene proteins c-rel; priority journal; article; support, u.s. gov't, p.h.s.
Journal Title: Cell
Volume: 80
Issue: 4
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 1995-02-24
Start Page: 573
End Page: 582
Language: English
DOI: 10.1016/0092-8674(95)90511-1
PUBMED: 7867065
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
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  1. Paul J Tempst
    324 Tempst