IκB-β regulates the persistent response in a biphasic activation of NF-κB Journal Article
| Authors: | Thompson, J. E.; Phillips, R. J.; Erdjument-Bromage, H.; Tempst, P.; Ghosh, S. |
| Article Title: | IκB-β regulates the persistent response in a biphasic activation of NF-κB |
| Abstract: | We have cloned the cDNA encoding IκB-β, one of the two major IκB isoforms in mammalian cells. The recombinant IκB-β protein interacts with equal affinity to p65 and c-Rel and does not exhibit a preference between these Rel proteins. Instead the primary difference between IκB-α and IκB-β is in their response to different inducers of NF-κB activity. One class of inducers causes rapid but transient activation of NF-κB by primarily affecting IκB-α complexes, whereas another class of inducers causes persistent activation of NF-κB by affecting both IκB-α and IκB-β complexes. Therefore, the overall activation of NF-κB consists of two overlapping phases, a transient phase mediated through IκB-α and a persistent phase mediated through IκB-β. © 1995. |
| Keywords: | protein phosphorylation; sequence analysis; dna-binding proteins; proto-oncogene proteins; nonhuman; comparative study; animal cell; animal; mammalia; mice; transcription initiation; protein binding; transcription factor; embryo development; immunoglobulin enhancer binding protein; gene expression regulation; molecular cloning; cloning, molecular; regulatory mechanism; amino acid sequence; molecular sequence data; sequence homology, amino acid; nf-kappa b; lung; dna, complementary; mammal cell; rabbits; proto-oncogene proteins c-rel; priority journal; article; support, u.s. gov't, p.h.s. |
| Journal Title: | Cell |
| Volume: | 80 |
| Issue: | 4 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 1995-02-24 |
| Start Page: | 573 |
| End Page: | 582 |
| Language: | English |
| DOI: | 10.1016/0092-8674(95)90511-1 |
| PUBMED: | 7867065 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
