The oncogene qin codes for a transcriptional repressor Journal Article
| Authors: | Li, J.; Chang, H. W.; Lai, E.; Parker, E. J.; Vogt, P. K. |
| Article Title: | The oncogene qin codes for a transcriptional repressor |
| Abstract: | The retroviral oncogene qin codes for a protein that belongs to the winged helix family of transcriptional regulators. The Qin protein is localized in the nucleus and binds to the same DNA consensus sequence as rat brain factor 1 (BF-1). Cellular Qin shows greater affinity to DNA than does viral Qin. Alone or fused to the DNA-binding domain of the yeast GAL4 protein, both Qin proteins act as transcriptional repressors. The major transcriptional repression domain maps to the region of amino acids 252–395 of viral Qin. © 1995, American Association for Cancer Research. All rights reserved. |
| Keywords: | oncoprotein; proto-oncogene proteins; nonhuman; protein analysis; protein dna binding; genetic transcription; transcription, genetic; nuclear proteins; dna; transcription regulation; amino acid sequence; molecular sequence data; electrophoretic mobility; retrovirus; virus protein; fungal proteins; virus oncogene; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Cancer Research |
| Volume: | 55 |
| Issue: | 23 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 1995-12-01 |
| Start Page: | 5540 |
| End Page: | 5544 |
| Language: | English |
| PUBMED: | 7585630 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
