Nodular spindle-cell vascular transformation of lymph nodes: A benign process occurring predominantly in retroperitoneal lymph nodes draining carcinomas that can simulate Kaposi's sarcoma or metastatic tumor Journal Article
| Authors: | Cook, P. D.; Czerniak, B.; Chan, J. K. C.; Mackay, B.; Ordóñez, N. G.; Ayala, A. G.; Rosai, J. |
| Article Title: | Nodular spindle-cell vascular transformation of lymph nodes: A benign process occurring predominantly in retroperitoneal lymph nodes draining carcinomas that can simulate Kaposi's sarcoma or metastatic tumor |
| Abstract: | We describe a vasoproliferative nodular spindle-cell lesion representing a variant of vascular transformation of lymph-node sinuses and designated a nodular spindle-cell vascular transformation of lymph nodes. The lesion is most frequently identified in retroperitoneal lymph nodes excised in association with radical nephrectomies for renal cell carcinoma, but it can also be present in association with other malignant tumors. Occasionally it is seen in superficial lymph nodes in patients with no history of malignant neoplasms. This lesion can be confused with Kaposi's sarcoma or with a metastatic sarcomatoid carcinoma because of its spindle-cell composition, cellular-ity, occasional high mitotic activity, and frequent occurrence in the regional lymphatic drainage of a known malignancy. |
| Keywords: | immunohistochemistry; adult; clinical article; controlled study; human tissue; aged; histopathology; paraaortic lymph node; electron microscopy; kidney carcinoma; nephrectomy; cell transformation; spindle cell; kaposi sarcoma; lymph node cell; human; male; female; article; nodular spindle-cell vascular transformation of lymph nodes; vascular lesions of lymph nodes |
| Journal Title: | American Journal of Surgical Pathology |
| Volume: | 19 |
| Issue: | 9 |
| ISSN: | 0147-5185 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1995-09-01 |
| Start Page: | 1010 |
| End Page: | 1020 |
| Language: | English |
| DOI: | 10.1097/00000478-199509000-00004 |
| PUBMED: | 7661274 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
