Cervical lymph node metastasis in high-grade transformation of head and neck adenoid cystic carcinoma: A collective international review Journal Article
| Authors: | Hellquist, H.; Skálová, A.; Barnes, L.; Cardesa, A.; Thompson, L. D. R.; Triantafyllou, A.; Williams, M. D.; Devaney, K. O.; Gnepp, D. R.; Bishop, J. A.; Wenig, B. M.; Suárez, C.; Rodrigo, J. P.; Coca-Pelaz, A.; Strojan, P.; Shah, J. P.; Hamoir, M.; Bradley, P. J.; Silver, C. E.; Slootweg, P. J.; Vander Poorten, V.; Teymoortash, A.; Medina, J. E.; Robbins, K. T.; Pitman, K. T.; Kowalski, L. P.; de Bree, R.; Mendenhall, W. M.; Eloy, J. A.; Takes, R. P.; Rinaldo, A.; Ferlito, A. |
| Article Title: | Cervical lymph node metastasis in high-grade transformation of head and neck adenoid cystic carcinoma: A collective international review |
| Abstract: | Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC-HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation. |
| Keywords: | lymphatic metastasis; adenocarcinoma; recurrence; dissection; salivary glands; neck; local; neoplasm recurrence; adenoid cystic carcinoma; fatal outcome; dedifferentiation; mucoepidermoid carcinoma; salivary-glands; of-the-literature; parotid-gland; analog; secretory carcinoma; histologic transformation; acinic cell-carcinoma; high-grade transformation; epithelial-myoepithelial carcinoma |
| Journal Title: | Advances in Therapy |
| Volume: | 33 |
| Issue: | 3 |
| ISSN: | 0741-238X |
| Publisher: | Springer |
| Date Published: | 2016-03-01 |
| Start Page: | 357 |
| End Page: | 368 |
| Language: | English |
| ACCESSION: | WOS:000374258600004 |
| DOI: | 10.1007/s12325-016-0298-5 |
| PROVIDER: | wos |
| PMCID: | PMC4833802 |
| PUBMED: | 26895332 |
| Notes: | Review -- Source: Wos |
