Melanoma and melanocytes: Pigmentation, tumor progression, and the immune response to cancer Journal Article
| Authors: | Vijayasaradhi, S.; Houghton, A. N. |
| Article Title: | Melanoma and melanocytes: Pigmentation, tumor progression, and the immune response to cancer |
| Abstract: | Melanoma is a remarkable model to study tumor progression. The normal cell counterpart, the melanocyte, can be readily cultured in vitro, and lesions representing benign precursors and early and late stages in progression are readily accessible for study in both in vitro and in vivo. There is an array of markers whose expression is tightly regulated during malignant transformation and tumor progression, including growth factors, their receptors, adhesion molecules, and cell surface enzymes. With regard to growth factors, bFGF is particularly interesting as a potential autocrine factor acquired during melanoma progression. The ability of melanoma to spread widely (and very rarely regress spontaneously) is legendary among oncologists. Melanoma can metastasize to almost any organ in the body (for instance, it is one of the few cancers that metastasizes regularly to the heart). Studies of melanoma have given important insights into the immune response to cancer and have formed significant paradigms for malignant transformation and progression of human tumors. These studies have also provided useful tools for dissecting cellular aspects of pigmentation and genetics and development of skin and coat color. This chapter reviews recent progress in the biology, genetics, and immunology of melanocytes and melanoma, with particular emphasis on advances that have implications for diagnosis and therapy of human disease. © 1995 Academic Press Inc. |
| Keywords: | disease course; review; pathophysiology; animal; melanoma; melanocyte; melanocytes; pathology; physiology; cell transformation, neoplastic; pigmentation; immunology; cell transformation; disease progression; human; support, u.s. gov't, p.h.s. |
| Journal Title: | Advances in Pharmacology |
| Volume: | 32 |
| ISSN: | 1054-3589 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1995-01-01 |
| Start Page: | 343 |
| End Page: | 374 |
| Language: | English |
| DOI: | 10.1016/s1054-3589(08)61017-0 |
| PUBMED: | 7748799 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
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