Adapting to stress — chaperome networks in cancer Journal Article


Authors: Joshi, S.; Wang, T.; Araujo, T. L. S.; Sharma, S.; Brodsky, J. L.; Chiosis, G.
Article Title: Adapting to stress — chaperome networks in cancer
Abstract: In this Opinion article, we aim to address how cells adapt to stress and the repercussions chronic stress has on cellular function. We consider acute and chronic stress-induced changes at the cellular level, with a focus on a regulator of cellular stress, the chaperome, which is a protein assembly that encompasses molecular chaperones, co-chaperones and other co-factors. We discuss how the chaperome takes on distinct functions under conditions of stress that are executed in ways that differ from the one-on-one cyclic, dynamic functions exhibited by distinct molecular chaperones. We argue that through the formation of multimeric stable chaperome complexes, a state of chaperome hyperconnectivity, or networking, is gained. The role of these chaperome networks is to act as multimolecular scaffolds, a particularly important function in cancer, where they increase the efficacy and functional diversity of several cellular processes. We predict that these concepts will change how we develop and implement drugs targeting the chaperome to treat cancer. © 2018, Macmillan Publishers Ltd., part of Springer Nature.
Journal Title: Nature Reviews Cancer
Volume: 18
Issue: 9
ISSN: 1474-175X
Publisher: Nature Publishing Group  
Date Published: 2018-09-01
Start Page: 562
End Page: 575
Language: English
DOI: 10.1038/s41568-018-0020-9
PROVIDER: scopus
PMCID: PMC6108944
PUBMED: 29795326
DOI/URL:
Notes: Review -- Export Date: 4 September 2018 -- Source: Scopus
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