Rapidly changing myeloma epidemiology in the general population: Increased incidence, older patients, and longer survival Journal Article


Authors: Turesson, I.; Bjorkholm, M.; Blimark, C. H.; Kristinsson, S.; Velez, R.; Landgren, O.
Article Title: Rapidly changing myeloma epidemiology in the general population: Increased incidence, older patients, and longer survival
Abstract: The incidence of multiple myeloma is characterized by a steep increase with advancing age. Dramatic improvements in survival have been reported in clinical trials; however, elderly patients are generally underrepresented in these. The aims of this study are to review patterns of incidence and survival in multiple myeloma in the general population. We searched PubMed for population-based studies on trends in incidence and survival published between January 1, 2000 and June 30, 2017 and based on regional or national cancer registries and report the following results of the review. The age-adjusted incidence of multiple myeloma has increased during the second half of the twentieth century in some countries but remained stable in areas with high case ascertainment and access to universal medical care. The crude incidence is increasing globally due to an aging population. Survival rates have improved, and 5-year relative survival rates are now around 50% and over 60% in patients 65-70 years or younger. Preliminary data suggest a 3-fold increase in the prevalence of multiple myeloma. We conclude that the number of multiple myeloma patients is increasing in the general population due to (i) aging populations and (ii) more patients living longer due to modern drugs. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Keywords: overall survival; multiple myeloma; incidence; prevalence; trends
Journal Title: European Journal of Haematology
Volume: 101
Issue: 2
ISSN: 0902-4441
Publisher: John Wiley & Sons  
Date Published: 2018-08-01
Start Page: 237
End Page: 244
Language: English
DOI: 10.1111/ejh.13083
PROVIDER: scopus
PUBMED: 29676004
PMCID: PMC6195866
DOI/URL:
Notes: Review -- Export Date: 4 September 2018 -- Source: Scopus
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  1. Carl Ola Landgren
    336 Landgren