| Abstract: |
Yearly, over 30,000 autologous and 20,000 allogeneic hematopoietic cell transplants (HCT) are performed worldwide. This chapter reviews vaccine guidelines published since 2009, the studies on which these guidelines were based, and the immunogenicity of vaccines in this patient population. It discusses areas in which additional data are needed. Current vaccine guidelines recommend three doses of tetanus/ diphtheria toxoid, IPV, and the protein-conjugated H. influenzae and pneumococcal vaccines due to multiple studies demonstrating a higher proportion of responders following three doses of each vaccine compared with one or two doses. The chapter reports studies that have shown the effect of age on vaccine response, particularly following the pneumococcal conjugate vaccine, rHBV, measles, and mumps. In vitro correlates of vaccine responses might allow earlier revaccination of patients with the requisite T- and B-cell populations and prevent premature vaccination and/or risk in patients unable to respond. © 2016 John Wiley & Sons, Ltd. All rights reserved. |
